Details

Autor(en) / Beteiligte

• Liu, Jenny
• Ho, Peh Joo
• Tan, Tricia Hui Ling
• Yeoh, Yen Shing
• Chew, Ying Jia
• Mohamed Riza, Nur Khaliesah
• Khng, Alexis Jiaying
• Goh, Su-Ann
• Wang, Yi
• Oh, Han Boon
• Chin, Chi Hui
• Kwek, Sing Cheer
• Zhang, Zhi Peng
• Ong, Desmond Luan Seng
• Quek, Swee Tian
• Tan, Chuan Chien
• Wee, Hwee Lin
• Li, Jingmei
• Iau, Philip Tsau Choong
• Hartman, Mikael
• Zheng, Yonglan

Titel

BREAst screening Tailored for HEr (BREATHE)-A study protocol on personalised risk-based breast cancer screening programme

Ist Teil von

• PloS one, 2022-03, Vol.17 (3), p.e0265965-e0265965

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Routine mammography screening is currently the standard tool for finding cancers at an early stage, when treatment is most successful. Current breast screening programmes are one-size-fits-all which all women above a certain age threshold are encouraged to participate. However, breast cancer risk varies by individual. The BREAst screening Tailored for HEr (BREATHE) study aims to assess acceptability of a comprehensive risk-based personalised breast screening in Singapore. Advancing beyond the current age-based screening paradigm, BREATHE integrates both genetic and non-genetic breast cancer risk prediction tools to personalise screening recommendations. BREATHE is a cohort study targeting to recruit ~3,500 women. The first recruitment visit will include questionnaires and a buccal cheek swab. After receiving a tailored breast cancer risk report, participants will attend an in-person risk review, followed by a final session assessing the acceptability of our risk stratification programme. Risk prediction is based on: a) Gail model (non-genetic), b) mammographic density and recall, c) BOADICEA predictions (breast cancer predisposition genes), and d) breast cancer polygenic risk score. For national implementation of personalised risk-based breast screening, exploration of the acceptability within the target populace is critical, in addition to validated predication tools. To our knowledge, this is the first study to implement a comprehensive risk-based mammography screening programme in Asia. The BREATHE study will provide essential data for policy implementation which will transform the health system to deliver a better health and healthcare outcomes.