Details

Autor(en) / Beteiligte

• Ronchini, Chiara
• Gandini, Sara
• Pasqualato, Sebastiano
• Mazzarella, Luca
• Facciotti, Federica
• Mapelli, Marina
• Frige', Gianmaria
• Passerini, Rita
• Pase, Luca
• Capizzi, Silvio
• Mastrilli, Fabrizio
• Orecchia, Roberto
• Natoli, Gioacchino
• Pelicci, Pier Giuseppe
• Gregori, Luisa

Titel

Lower probability and shorter duration of infections after COVID-19 vaccine correlate with anti-SARS-CoV-2 circulating IgGs

Ist Teil von

• PloS one, 2022-01, Vol.17 (1), p.e0263014-e0263014

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• The correlation between immune responses and protection from SARS-CoV-2 infections and its duration remains unclear. We performed a sanitary surveillance at the European Institute of Oncology (IEO) in Milan over a 17 months period. Pre-vaccination, in 1,493 participants, we scored 266 infections (17.8%) and 8 possible reinfections (3%). Post-vaccination, we identified 30 infections in 2,029 vaccinated individuals (1.5%). We report that the probability of infection post-vaccination is i) significantly lower compared to natural infection, ii) associated with a significantly shorter median duration of infection than that of first infection and reinfection, iii) anticorrelated with circulating antibody levels.