PloS one, 2022-01, Vol.17 (1), p.e0262916-e0262916
2022
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Details
- Autor(en) / Beteiligte
- Titel
- Dietary rescue of adult behavioral deficits in the Fmr1 knockout mouse
- Ist Teil von
- PloS one, 2022-01, Vol.17 (1), p.e0262916-e0262916
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2022
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The current study aimed to further address important questions regarding the therapeutic efficacy of omega-3 fatty acids for various behavioral and neuroimmune aspects of the Fmr1 phenotype. To address these questions, our experimental design utilized two different omega-3 fatty acid administration timepoints, compared to both standard laboratory chow controls ("Standard") and a diet controlling for the increase in fat content ("Control Fat"). In the first paradigm, post-weaning supplementation (after postnatal day 21) with the omega-3 fatty acid diet ("Omega-3") reversed deficits in startle threshold, but not deficits in prepulse inhibition, and the effect on startle threshold was not specific to the Omega-3 diet. However, post-weaning supplementation with both experimental diets also impaired acquisition of a fear response, recall of the fear memory and contextual fear conditioning compared to the Standard diet. The post-weaning Omega-3 diet reduced hippocampal expression of IL-6 and this reduction of IL-6 was significantly associated with diminished performance in the fear conditioning task. In the perinatal experimental paradigm, the Omega-3 diet attenuated hyperactivity and acquisition of a fear response. Additionally, perinatal exposure to the Control Fat diet (similar to a "Western" diet) further diminished nonsocial anxiety in the Fmr1 knockout. This study provides significant evidence that dietary fatty acids throughout the lifespan can significantly impact the behavioral and neuroimmune phenotype of the Fmr1 knockout model.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0262916Titel-ID: cdi_plos_journals_2623591458
- Format
- –
- Schlagworte
- Animals, Anxiety - diet therapy, Anxiety - genetics, Anxiety - metabolism, Anxiety - physiopathology, Autism, Behavior, Behavior, Animal - drug effects, Bioavailability, Biology and Life Sciences, Conditioning, Cytokines, Design of experiments, Diet, Dietary supplements, Experimental design, Fatty acids, Fatty Acids, Omega-3 - pharmacology, Fear, Fear conditioning, FMR1 protein, Fragile X Mental Retardation Protein - genetics, Fragile X Mental Retardation Protein - metabolism, Gene expression, Genetic aspects, Genotype & phenotype, Health aspects, Hippocampus, Hippocampus - metabolism, Hippocampus - physiopathology, Hyperactivity, Intellectual disabilities, Interleukin 6, Laboratory animals, Life span, Lipid metabolism, Maze Learning - drug effects, Medicine and Health Sciences, Mice, Mice, Knockout, Mutation, Neurosciences, Omega-3 fatty acids, Perinatal exposure, Phenotype, Phenotypes, Questions, Social Sciences, Weaning