Details

Autor(en) / Beteiligte

• Kober, Christina
• Manni, Sandro
• Wolff, Svenja
• Barnes, Thomas
• Mukherjee, Shatanik
• Vogel, Thomas
• Hoenig, Lea
• Vogel, Peter
• Hahn, Aaron
• Gerlach, Michaela
• Vey, Martin
• Widmer, Eleonora
• Keiner, Björn
• Schuetz, Patrick
• Roth, Nathan
• Kalina, Uwe
• Nasrallah, Gheyath K.

Titel

IgG3 and IgM Identified as Key to SARS-CoV-2 Neutralization in Convalescent Plasma Pools

Ist Teil von

• PloS one, 2022-01, Vol.17 (1), p.e0262162-e0262162

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Analysis of convalescent plasma derived from individuals has shown that IgG3 has the most important role in binding to SARS-CoV-2 antigens; however, this has not yet been confirmed in large studies, and the link between binding and neutralization has not been confirmed. By analyzing plasma pools consisting of 247-567 individual convalescent donors, we demonstrated the binding of IgG3 and IgM to Spike-1 protein and the receptor-binding domain correlates strongly with viral neutralization in vitro. Furthermore, despite accounting for only approximately 12% of total immunoglobulin mass, collectively IgG3 and IgM account for approximately 80% of the total neutralization. This may have important implications for the development of potent therapies for COVID-19, as it indicates that hyperimmune globulins or convalescent plasma donations with high IgG3 concentrations may be a highly efficacious therapy.