Details

Autor(en) / Beteiligte

• Zuil, María
• Benítez, Iván D
• Cabo-Gambín, Ramón
• Manzano Senra, Carlos
• Moncusí-Moix, Anna
• Gort-Paniello, Clara
• de Gonzalo-Calvo, David
• Molinero, Marta
• Vengoechea Aragoncillo, Jose Javier
• Comella, Thais
• de Batlle, Jordi
• Torres, Gerard
• Torres, Antoni
• Barbé, Ferrán
• González, Jessica
• Zivkovic, Aleksandar R.

Titel

Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort

Ist Teil von

• PloS one, 2021-10, Vol.16 (10), p.e0258918-e0258918

Ort / Verlag

San Francisco: Public Library of Science

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total of 421 consecutive patients were included, 188 during the first period (March-May 2020) and 233 in the second wave (July-December 2020). Clinical, epidemiological, prognostic and therapeutic data were compared. Patients of the first outbreak were older and more comorbid, presented worse PaO2/FiO2 ratio and an increased creatinine and D-dimer levels at hospital admission. The hospital stay was shorter (14.5[8;29] vs 8[6;14] days, p<0.001), ICU admissions (31.9% vs 13.3%, p<0.001) and the number of patients who required mechanical ventilation (OR = 0.12 [0.05–10.26]; p<0.001) were reduced. There were no significant differences in hospital and 30-day after discharge mortality (adjusted HR = 1.56; p = 0.1056) or hospital readmissions. New treatments and clinical strategies appear to improve hospital length, ICU admissions and the requirement for mechanical ventilation. However, we did not observe differences in mortality or readmissions.