Details

Autor(en) / Beteiligte

• Deloison, Benjamin
• Arthuis, Chloé
• Benchimol, Gabriel
• Balvay, Daniel
• Bussieres, Laurence
• Millischer, Anne-Elodie
• Grévent, David
• Butor, Cécile
• Chalouhi, Gihad
• Mahallati, Houman
• Hélénon, Olivier
• Tavitian, Bertrand
• Clement, Olivier
• Ville, Yves
• Siauve, Nathalie
• Salomon, Laurent Julien
• Paules, Cristina

Titel

Human placental perfusion measured using dynamic contrast enhancement MRI

Ist Teil von

• PloS one, 2021-09, Vol.16 (9), p.e0256769-e0256769

Ort / Verlag

San Francisco: Public Library of Science

Erscheinungsjahr

2021

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• To evaluate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and measure values of in vivo placental perfusion in women. This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before termination of pregnancies at 16 to 34 weeks gestational age (GA). Quantitative analysis was performed using one-compartment intravascular modeling. DCE perfusion parameters were analyzed across GA and were compared in IUGR and AGA fetuses. 134 patients were enrolled. After quality control check, 62 DCE MRI were analyzed including 48 and 14 pregnancies with normal and abnormal karyotypes, respectively. Mean placental blood flow was 129±61 mL/min/100ml in cases with normal karyotypes. Fetuses affected by IUGR (n = 13) showed significantly lower total placental blood flow values than AGA fetuses (n = 35) (F .sub.total = 122±88 mL/min versus 259±34 mL/min, p = 0.002). DCE perfusion parameters showed a linear correlation with GA. Measuring placental perfusion in vivo is possible using DCE MRI. Although this study has many limitations it gives us the first DCE MRI values that provide a potential standard for future research into placental perfusion methods and suggests that placental functional parameters are altered in IUGR pregnancies.