Details

Autor(en) / Beteiligte

• Somoza, Maria Luisa
• Pérez-Sánchez, Natalia
• Victorio-Puche, Laura
• Martín-Pedraza, Laura
• Esteban Rodríguez, Angel
• Blanca-López, Natalia
• Abel Fernández González, Eva
• Ruano-Zaragoza, María
• Prieto-Moreno Pfeifer, Ana
• Fernández Caldas, Enrique
• Morán Morales, Miriam
• Fernández Sánchez, Francisco Javier
• López Sánchez, José Damián
• Jiménez Rodríguez, Teodorikez Wilfox
• Subiza Garrido-Lestache, José Luis
• Canto Díez, Gabriela
• Blanca Gómez, Miguel
• Cornejo-García, José Antonio
• Plavec, Davor

Titel

Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population

Ist Teil von

• PloS one, 2021-08, Vol.16 (8), p.e0255305-e0255305

Ort / Verlag

San Francisco: Public Library of Science

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Peach tree allergens are present in fruit, pollen, branches, and leaves, and can induce systemic, respiratory, cutaneous, and gastrointestinal symptoms. We studied the capacity of peach fruit/Pru p 1, Pru p 3, Pru p 4, Pru p 7 and peach pollen/Pru p 9 for inducing symptoms following oral or respiratory exposure in a large group of subjects. We included 716 adults (aged 21 to 83 y.o.) exposed to peach tree pollen and fruit intake in the study population. Participants completed a questionnaire and were skin tested with a panel of inhalant and food allergens, including peach tree pollen, Pru p 9 and peach fruit skin extract. Immunoglobulin E antibodies (SIgE) to Pru p 1, Pru p 3, Pru p 4 and Pru p 7 were quantified. Sensitised subjects underwent oral food challenge with peach fruit and nasal provocation test with peach tree pollen and Pru p 9. The prevalence of sensitisation to peach fruit was 5% and most of these had SIgE to Pru p 3, with a very low proportion to Pru p 4 SIgE and no SIgE to Pru p 1 and Pru p 7. In only 1.8%, anaphylaxis was the clinical entity induced. Cases with positive skin tests to peach and SIgE to Pru p 3 presented a good tolerance after oral challenge with peach fruit. The prevalence of skin sensitisation to peach tree pollen was 22%, with almost half recognising Pru p 9. This induced respiratory symptoms in those evaluated by nasal provocation. In a large population group exposed to peach fruit and peach tree pollen, most individuals were tolerant, even in those with SIgE to Pru p 3. A positive response to Pru p 9 was associated with respiratory allergy.