Details

Autor(en) / Beteiligte

• Rombouts, Jan
• Gelens, Lendert
• Csikász-Nagy, Attila

Titel

Dynamic bistable switches enhance robustness and accuracy of cell cycle transitions

Ist Teil von

• PLoS computational biology, 2021-01, Vol.17 (1), p.e1008231-e1008231

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2021

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Bistability is a common mechanism to ensure robust and irreversible cell cycle transitions. Whenever biological parameters or external conditions change such that a threshold is crossed, the system abruptly switches between different cell cycle states. Experimental studies have uncovered mechanisms that can make the shape of the bistable response curve change dynamically in time. Here, we show how such a dynamically changing bistable switch can provide a cell with better control over the timing of cell cycle transitions. Moreover, cell cycle oscillations built on bistable switches are more robust when the bistability is modulated in time. Our results are not specific to cell cycle models and may apply to other bistable systems in which the bistable response curve is time-dependent.