Details

Autor(en) / Beteiligte

• King, Christopher S
• Sahjwani, Dhwani
• Brown, A Whitney
• Feroz, Saad
• Cameron, Paula
• Osborn, Erik
• Desai, Mehul
• Djurkovic, Svetolik
• Kasarabada, Aditya
• Hinerman, Rachel
• Lantry, James
• Shlobin, Oksana A
• Ahmad, Kareem
• Khangoora, Vikramjit
• Aryal, Shambhu
• Collins, A Claire
• Speir, Alan
• Nathan, Steven
• Lazzeri, Chiara

Titel

Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure

Ist Teil von

• PloS one, 2020-11, Vol.15 (11), p.e0242651-e0242651

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine clinical characteristics and outcomes of patients with COVID-19 managed with invasive mechanical ventilation in an appropriately resourced US health care system. Outcomes of COVID-19 infected patients requiring mechanical ventilation treated within the Inova Health System between March 5, 2020 and April 26, 2020 were evaluated through an electronic medical record review. 1023 COVID-19 positive patients were admitted to the Inova Health System during the study period. Of these, 164 (16.0%) were managed with invasive mechanical ventilation. All patients were followed to definitive disposition. 70/164 patients (42.7%) had died and 94/164 (57.3%) were still alive. Deceased patients were older (median age of 66 vs. 55, p <0.0001) and had a higher initial d-dimer (2.22 vs. 1.31, p = 0.005) and peak ferritin levels (2998 vs. 2077, p = 0.016) compared to survivors. 84.3% of patients over 70 years old died in the hospital. Conversely, 67.4% of patients age 70 or younger survived to hospital discharge. Younger age, non-Caucasian race and treatment at a tertiary care center were all associated with survivor status. Mortality of patients with COVID-19 requiring invasive mechanical ventilation is high, with particularly daunting mortality seen in patients of advanced age, even in a well-resourced health care system. A substantial proportion of patients requiring invasive mechanical ventilation were not of advanced age, and this group had a reasonable chance for recovery.