Details

Autor(en) / Beteiligte

• Lee, Jia-Jung
• Wei, Yu-Ju
• Lin, Ming-Yen
• Niu, Sheng-Wen
• Hsu, Po-Yao
• Huang, Jiun-Chi
• Jang, Tyng-Yuan
• Yeh, Ming-Lun
• Huang, Ching-I
• Liang, Po-Cheng
• Lin, Yi-Hung
• Hsieh, Ming-Yen
• Hsieh, Meng-Hsuan
• Chen, Szu-Chia
• Dai, Chia-Yen
• Lin, Zu-Yau
• Chen, Shinn-Cherng
• Huang, Jee-Fu
• Chang, Jer-Ming
• Hwang, Shang-Jyh
• Huang, Chung-Feng
• Chiu, Yi-Wen
• Chuang, Wan-Long
• Yu, Ming-Lung
• Kanda, Tatsuo

Titel

The applicability of non-invasive methods for assessing liver fibrosis in hemodialysis patients with chronic hepatitis C

Ist Teil von

• PloS one, 2020-11, Vol.15 (11), p.e0242601-e0242601

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• The accurate assessment of liver fibrosis among hemodialysis patients with chronic hepatitis C (CHC) is important for both treatment and for follow up strategies. Applying the non-invasive methods in general population with viral hepatitis have been successful but the applicability of the aminotransferase/platelet ratio index (APRI) or the fibrosis-4 index (FIB-4) in hemodialysis patients need further evaluation. We conducted a prospective, multi-center, uremic cohort to verify the applicability of APRI and FIB-4 in identifying liver fibrosis by reference with the standard transient elastography (TE) measures. There were 116 CHC cases with valid TE were enrolled in our analysis. 46 cases (39.6%) were classified as F1, 35 cases (30.2%) as F2, 11 cases (9.5%) as F3, and 24 cases (20.7%) as F4, respectively. The traditional APRI and FIB-4 criteria did not correctly identify liver fibrosis. The optimal cut-off value of APRI was 0.28 and of FIB-4 was 1.91 to best excluding liver cirrhosis with AUC of 76% and 77%, respectively. The subgroup analysis showed that female CHC hemodialysis patients had better diagnostic accuracy with 74.1% by APRI. And CHC hemodialysis patients without hypertension had better diagnostic accuracy with 78.6% by FIB-4. This study confirmed the traditional category level of APRI and FIB-4 were unable to identify liver fibrosis of CHC hemodialysis patients. With the adjusted cut-off value, APRI and FIB-4 still showed suboptimal diagnostic accuracy. Our results suggest the necessary of TE measures for liver fibrosis in the CHC uremic population.