Details

Autor(en) / Beteiligte

• Vogelezang, Suzanne
• Bradfield, Jonathan P
• Ahluwalia, Tarunveer S
• Curtin, John A
• Lakka, Timo A
• Grarup, Niels
• Scholz, Markus
• van der Most, Peter J
• Monnereau, Claire
• Stergiakouli, Evie
• Heiskala, Anni
• Horikoshi, Momoko
• Fedko, Iryna O
• Vilor-Tejedor, Natalia
• Cousminer, Diana L
• Standl, Marie
• Wang, Carol A
• Viikari, Jorma
• Geller, Frank
• Íñiguez, Carmen
• Pitkänen, Niina
• Chesi, Alessandra
• Bacelis, Jonas
• Yengo, Loic
• Torrent, Maties
• Ntalla, Ioanna
• Helgeland, Øyvind
• Selzam, Saskia
• Vonk, Judith M
• Zafarmand, Mohammed H
• Heude, Barbara
• Farooqi, Ismaa Sadaf
• Alyass, Akram
• Beaumont, Robin N
• Have, Christian T
• Rzehak, Peter
• Bilbao, Jose Ramon
• Schnurr, Theresia M
• Barroso, Inês
• Bønnelykke, Klaus
• Beilin, Lawrence J
• Carstensen, Lisbeth
• Charles, Marie-Aline
• Chawes, Bo
• Clément, Karine
• Closa-Monasterolo, Ricardo
• Custovic, Adnan
• Eriksson, Johan G
• Escribano, Joaquin
• Groen-Blokhuis, Maria
• Grote, Veit
• Gruszfeld, Dariusz
• Hakonarson, Hakon
• Hansen, Torben
• Hattersley, Andrew T
• Hollensted, Mette
• Hottenga, Jouke-Jan
• Hyppönen, Elina
• Johansson, Stefan
• Joro, Raimo
• Kähönen, Mika
• Karhunen, Ville
• Kiess, Wieland
• Knight, Bridget A
• Koletzko, Berthold
• Kühnapfel, Andreas
• Landgraf, Kathrin
• Langhendries, Jean-Paul
• Lehtimäki, Terho
• Leinonen, Jaakko T
• Li, Aihuali
• Lindi, Virpi
• Lowry, Estelle
• Bustamante, Mariona
• Medina-Gomez, Carolina
• Melbye, Mads
• Michaelsen, Kim F
• Morgen, Camilla S
• Mori, Trevor A
• Nielsen, Tenna R H
• Niinikoski, Harri
• Oldehinkel, Albertine J
• Pahkala, Katja
• Panoutsopoulou, Kalliope
• Pedersen, Oluf
• Pennell, Craig E
• Power, Christine
• Reijneveld, Sijmen A
• Rivadeneira, Fernando
• Simpson, Angela
• Sly, Peter D
• Stokholm, Jakob
• Teo, Kook K
• Thiering, Elisabeth
• Timpson, Nicholas J
• Uitterlinden, André G
• van Beijsterveldt, Catharina E M
• van Schaik, Barbera D C
• Vaudel, Marc
• Verduci, Elvira
• Copenhaver, Gregory P.

Titel

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

Ist Teil von

• PLoS genetics, 2020-10, Vol.16 (10), p.e1008718

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.