Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Zur Ergebnisliste
Ergebnis 2 von 11
Open Access
    Datensatz exportieren als...
  • BibTeX
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
PLoS genetics, 2020-10, Vol.16 (10), p.e1008718
2020
Volltextzugriff (PDF)

Details

Autor(en) / Beteiligte
Titel
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits
Ist Teil von
  • PLoS genetics, 2020-10, Vol.16 (10), p.e1008718
Ort / Verlag
United States: Public Library of Science
Erscheinungsjahr
2020
Quelle
Free E-Journal (出版社公開部分のみ）
Beschreibungen/Notizen
  • The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.
Sprache
Englisch
Identifikatoren
ISSN: 1553-7404, 1553-7390
eISSN: 1553-7404
DOI: 10.1371/journal.pgen.1008718
Titel-ID: cdi_plos_journals_2460112751
Format
–
Schlagworte
Adolescent, Adult, Analysis, Asthma, Bioinformatics, Biology and Life Sciences, Birth weight, Blood Pressure, Body Mass Index, Cardiometabolic Risk Factors, Cardiovascular Diseases - genetics, Cardiovascular Diseases - pathology, Child, Child, Preschool, Children, Comparative analysis, Demographic aspects, Diabetes, Diabetes mellitus (non-insulin dependent), Diabetes Mellitus, Type 2 - genetics, Diabetes Mellitus, Type 2 - pathology, Diagnosis, Environmental health, Epidemiology, Female, Funding, Genetic factors, Genetic Predisposition to Disease, Genetics, Genome-wide association studies, Genome-Wide Association Study - methods, Genomes, Gynecology, Heritability, Hospitals, Humans, Life Sciences, Male, Medical research, Medicine, Medicine and Health Sciences, Menarche, Menarche - genetics, Mendelian Randomization Analysis, Metabolic diseases, Metabolic disorders, Metabolism, Monosaccharide Transport Proteins - genetics, Nedd4 Ubiquitin Protein Ligases - genetics, Obstetrics, Obstetrics, Gynecology and Reproductive Medicine, Pediatrics, Physical Sciences, Physiology, Public health, Quantitative trait loci, Reproduktionsmedicin och gynekologi, Research and Analysis Methods, Waist-Hip Ratio

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX