PloS one, 2020-09, Vol.15 (9), p.e0239231-e0239231
2020
Details
- Autor(en) / Beteiligte
- Titel
- Stress hormones or general well-being are not altered in immune-deficient mice lacking either T- and B- lymphocytes or Interferon gamma signaling if kept under specific pathogen free housing conditions
- Ist Teil von
- PloS one, 2020-09, Vol.15 (9), p.e0239231-e0239231
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2020
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- It is controversially discussed whether immune-deficient mice experience severity in the absence of infection. Because a comprehensive analysis of the well-being of immune-deficient mice under specific pathogen free conditions is missing, we used a multi-parametric test analyzing, corticosterone, weight, nest building and facial expression over a period of 9 month to determine the well-being of two immune-deficient mouse lines (recombination activating gene 2- and interferon gamma receptor-deficient mice). We do not find evidence for severity when comparing immune-deficient mice to their heterozygous immune-competent littermates. Our data challenge the assumption that immune-deficiency per se regardless of housing conditions causes severity. Based on our study we propose to use objective non-invasive parameters determined by laboratory animal science for decisions concerning severity of immune-deficient mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0239231Titel-ID: cdi_plos_journals_2447526977
- Format
- –
- Schlagworte
- Animal welfare, Animals, B cells, B-Lymphocytes - immunology, Biology and Life Sciences, Corticosterone, Corticosterone - genetics, Corticosterone - immunology, DNA-Binding Proteins - genetics, Females, Gene therapy, Genetic aspects, Genotype & phenotype, Health aspects, Hormones, House mouse, Housing, Housing conditions, Humans, Immune system, Immunocompromised host, Immunology, Infection, Infections - genetics, Infections - immunology, Interferon, Interferon gamma, Interferon gamma Receptor, Interferon-gamma - genetics, Kidney - metabolism, Kidney - pathology, Laboratory animals, Lymphocytes, Lymphocytes B, Lymphocytes T, Males, Medical research, Medicine and Health Sciences, Mice, Mice, SCID - genetics, Mice, SCID - immunology, Nest building, Pain - genetics, Pain - pathology, Pathogens, Pathology, Receptors, Interferon - deficiency, Receptors, Interferon - genetics, Recombination, Risk factors, Signal Transduction - genetics, Social Sciences, Specific pathogen free, Stress (Psychology), T cells, T-Lymphocytes - immunology, Testosterone - genetics, Veterinary medicine