PloS one, 2020-05, Vol.15 (5), p.e0233693-e0233693
2020
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Details
- Autor(en) / Beteiligte
- Titel
- Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission
- Ist Teil von
- PloS one, 2020-05, Vol.15 (5), p.e0233693-e0233693
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2020
- Quelle
- EZB Electronic Journals Library
- Beschreibungen/Notizen
- Efavirenz-based first-line regimens have been widely used for children ≥3 years of age starting antiretroviral therapy, despite possible resistance with prior exposure to non-nucleoside reverse transcriptase inhibitors for prevention of mother-to-child transmission (PMTCT). We used logistic regression to examine the association between PMTCT exposure and viral failure (VF) defined as two consecutive viral loads (VL)>1000 copies/ml between 6-18 months on ART. Children with previous nevirapine exposure for PMTCT were not at higher risk of VF compared to unexposed children (adjusted Odds Ratio (aOR): 0.79; 95% CI:0.56, 1.11).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0233693Titel-ID: cdi_plos_journals_2407761704
- Format
- –
- Schlagworte
- Acquired immune deficiency syndrome, Adults, Age, AIDS, AIDS research, Antiretroviral agents, Antiretroviral drugs, Antiretroviral therapy, Antiviral agents, Biology and Life Sciences, Children, Children & youth, Childrens health, Collaboration, Drug dosages, Drug resistance, Drug therapy, Efavirenz, Epidemiology, Exposure, Health aspects, Health sciences, HIV, Hospitals, Human immunodeficiency virus, Infectious diseases, Maternal-fetal exchange, Medicine, Medicine and Health Sciences, Nevirapine, Non-nucleoside reverse transcriptase inhibitors, Patient outcomes, Pediatric HIV infections, Pediatrics, People and Places, Prevention, Public health, Public sector, Reproductive health, RNA-directed DNA polymerase, Tuberculosis