Details

Autor(en) / Beteiligte

• Imai, Koubun
• Kimura, Sota
• Kiryu, Yoko
• Watanabe, Aki
• Kinai, Ei
• Oka, Shinichi
• Kikuchi, Yoshimi
• Kimura, Satoshi
• Ogata, Mikiko
• Takano, Misao
• Minamimoto, Ryogo
• Hotta, Masatoshi
• Yokoyama, Kota
• Noguchi, Tomoyuki
• Komatsu, Kensuke
• Albano, Domenico

Titel

Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients

Ist Teil von

• PloS one, 2020-03, Vol.15 (3), p.e0230292-e0230292

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2020

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• This single-institution cross-sectional study aimed to grasp the prevalence and features of neurocognitive dysfunction in HIV-infected hemophilia patients in Japan. We conducted neuropsychological tests and medical examinations in 56 HIV-infected hemophilia patients who received outpatient treatment at the AIDS Clinical Center, National Center for Global Health and Medicine. A total of 388 HIV-infected non-hemophilia patients who received outpatient treatment at the same institution were included as a control group. To investigate sites responsible for neurocognitive dysfunction in HIV-infected hemophilia patients using brain FDG-PET/CT scans, the accumulation of FDG in each brain region was compared. Approximately 50% of HIV-infected hemophilia patients had neurocognitive dysfunction. The prevalence of asymptomatic neurocognitive impairment was high (34%). Neurocognitive dysfunction was associated with educational level in HIV-infected hemophilia patients. In the symptomatic group, hemophilic arthropathy and history of cerebrovascular disorders were associated with neurocognitive dysfunction. Left temporal lobe function was reduced in the symptomatic group.