Details

Autor(en) / Beteiligte

• Dos Santos, Jéssica Cristina
• Leite Quixabeira, Valéria Bernadete
• Teodoro Silva, Muriel Vilela
• Damen, Michelle S M A
• Schraa, Kiki
• Jaeger, Martin
• Oosting, Marije
• Keating, Samuel T
• Dorta, Miriam Leandro
• Alves Pinto, Sebastião
• Bugalho Duarte, Fernanda
• de Araújo Pereira, Ledice Inácia
• Netea, Mihai G
• Ribeiro-Dias, Fátima
• Joosten, Leo A B
• Caljon, Guy

Titel

Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis

Ist Teil von

• PLoS neglected tropical diseases, 2020-02, Vol.14 (2), p.e0008029

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Interleukin-32 is a novel inflammatory mediator that has been described to be important in the immunopathogenesis and control of infections caused by Leishmania parasites. By performing experiments with primary human cells in vitro, we demonstrate that the expression of IL-32 isoforms is dependent on the time exposed to L. amazonensis and L. braziliensis antigens. Moreover, for the first time we show the functional consequences of three different genetic variations in the IL32 (rs4786370, rs4349147, rs1555001) modulating IL-32γ expression, influencing innate and adaptive cytokine production after Leishmania exposure. Using a Brazilian cohort of 107 American Tegumentary Leishmaniasis patients and a control cohort of 245 healthy individuals, the IL32 rs4786370 genetic variant was associated with protection against ATL, whereas the IL32 rs4349147 was associated with susceptibility to the development of localized cutaneous and mucosal leishmaniasis. These novel insights may help improve therapeutic strategies and lead to benefits for patients suffering from Leishmania infections.