Details

Autor(en) / Beteiligte

• Guimarães, Maria Fernanda Brandão Resende
• Pinto, Maria Raquel da Costa
• Resende, Gustavo Gomes
• Machado, Carla Jorge
• Vargas-Santos, Ana Beatriz
• Amorim, Rodrigo Balbino Chaves
• Gomides, Ana Paula Monteiro
• Albuquerque, Cleandro Pires de
• Bértolo, Manoel Barros
• Júnior, Paulo Louzada
• Santos, Isabela Araújo
• Giorgi, Rina Dalva Neubarth
• Saciloto, Nathalia de Carvalho
• Radominski, Sebastião Cezar
• Borghi, Fernanda Maria
• Bonfiglioli, Karina Rossi
• Silva, Henrique Carriço da
• Sauma, Maria de Fátima L da Cunha
• Sauma, Marcel Lobato
• Medeiros, Júlia Brito de
• Pereira, Ivânio Alves
• Castro, Gláucio Ricardo Werner de
• Brenol, Claiton Viegas
• Xavier, Ricardo Machado
• Mota, Licia Maria Henrique
• Castelar-Pinheiro, Geraldo da Rocha
• Navarini, Luca

Titel

Discordance between the patient's and physician's global assessment in rheumatoid arthritis: Data from the REAL study-Brazil

Ist Teil von

• PloS one, 2020-03, Vol.15 (3), p.e0230317-e0230317

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2020

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Discordance between patient's global assessment (PtGA) and physician's global assessment (PhGA) has been described in rheumatoid arthritis (RA). Understanding the reasons for this discrepancy is important in the context of treat-to-target treatment strategy. To assess the determinants of PtGA and PhGA and factors associated with discordance between them. The REAL study included RA patients from Brazilian public health centers. Clinical, laboratory and outcomes measures were collected. PtGA and the PhGA were rated on a visual analog scale and analyzed. Three groups were defined: no discordance (difference between PtGA and PhGA within 3 cm), positive discordance (PtGA exceeding PhGA by >3 cm), and negative discordance (PtGA less than PhGA by >3 cm). Multivariate regression analysis was used to identify determinants of PtGA and PhGA and their discordance. 1115 patients (89,4% female, mean age 56.7y and median disease duration of 12.7y) were enrolled. Two factors were associated with PtGA in the final multivariate model: one point increase in the pain scale leads to an increase of 0.62 in PtGA; one point increase in HAQ increases by 9,25 points the PtGA. The factors associated with PhGA were pain scale, number of tender and swollen joints (NTJ and NSJ), positive RF, ESR, HAQ-DI and use of corticosteroids. Discordance between patient and physician was found in 30.52%: positive discordance in 24.6% and negative discordance in 5.92%. An increase of one point in the NSJ was associated with a 12% increase in the chance of negative discordance. The chance of positive discordance increased by 90% and 2% for each unit increased in HAQ-DI and pain scale respectively. Finally, the chance of positive discordance decreased by 3% for each point increased in NTJ and by 15% for each point increased in NSJ. In one-third of the assessments, there was disagreement between PtGA and PhGA (a positive discordance was found in 80% of them). Pain and function were determinants for patients to estimate disease activity, while swollen joints was the main factor related to a worse physician's evaluation. These data show how different can be the perspectives of patients and assistants.