PLoS biology, 2020-01, Vol.18 (1), p.e3000596-e3000596
2020
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Details
- Autor(en) / Beteiligte
- Titel
- SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces
- Ist Teil von
- PLoS biology, 2020-01, Vol.18 (1), p.e3000596-e3000596
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2020
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Neurons store information by changing synaptic input weights. In addition, they can adjust their membrane excitability to alter spike output. Here, we demonstrate a role of such "intrinsic plasticity" in behavioral learning in a mouse model that allows us to detect specific consequences of absent excitability modulation. Mice with a Purkinje-cell-specific knockout (KO) of the calcium-activated K+ channel SK2 (L7-SK2) show intact vestibulo-ocular reflex (VOR) gain adaptation but impaired eyeblink conditioning (EBC), which relies on the ability to establish associations between stimuli, with the eyelid closure itself depending on a transient suppression of spike firing. In these mice, the intrinsic plasticity of Purkinje cells is prevented without affecting long-term depression or potentiation at their parallel fiber (PF) input. In contrast to the typical spike pattern of EBC-supporting zebrin-negative Purkinje cells, L7-SK2 neurons show reduced background spiking but enhanced excitability. Thus, SK2 plasticity and excitability modulation are essential for specific forms of motor learning.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1545-7885, 1544-9173eISSN: 1545-7885DOI: 10.1371/journal.pbio.3000596Titel-ID: cdi_plos_journals_2355998112
- Format
- –
- Schlagworte
- Action Potentials - genetics, Adaptation, Animals, Behavioral plasticity, Biology and Life Sciences, Calcium, Cerebellar plasticity, Cerebellum, Cerebellum - cytology, Cerebellum - metabolism, Excitability, Eyelid, Eyelid conditioning, Female, Firing pattern, Learning, Learning - physiology, Long-term depression, Male, Medicine and Health Sciences, Memory, Memory - physiology, Mice, Mice, Inbred C57BL, Mice, Knockout, Modulation, Motor Activity - physiology, Motor skill learning, Neurobiology, Neuronal Plasticity - physiology, Neurons, Neurosciences, Plastic properties, Plasticity, Potassium channels, Potentiation, Purkinje cells, Purkinje Cells - metabolism, Reflex, Vestibulo-Ocular, Research and Analysis Methods, Small-Conductance Calcium-Activated Potassium Channels - metabolism, Small-Conductance Calcium-Activated Potassium Channels - physiology, Social Sciences, Spikes, Vestibulo-ocular reflex