PloS one, 2019-12, Vol.14 (12), p.e0226802-e0226802
2019
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- Autor(en) / Beteiligte
- Titel
- Interaction between BDNF val66met polymorphism and personality on long-term cardiac outcomes in patients with acute coronary syndrome
- Ist Teil von
- PloS one, 2019-12, Vol.14 (12), p.e0226802-e0226802
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The prognostic role of BDNF val66met polymorphism on long-term cardiac outcomes in acute coronary syndrome (ACS) has been unclear. Environmental factors may modify the association, but these have not been investigated to date. This study aimed to investigate the potential interactive effects of BDNF val66met polymorphism and personality traits, one of the main environmental prognostic factors of ACS, on major adverse cardiac events (MACEs) in patients with ACS. A total of 611 patients with recent ACS were recruited at a university hospital in Korea. Baseline evaluations from 2007 to 2012 assessed BDNF val66met polymorphism and personality using the Big Five Inventory, which yielded two personality clusters (resilient and vulnerable) and five dimensions (extraversion, agreeableness, conscientiousness, neuroticism, and openness). Over a 5~12 year follow-up after the index ACS, times to MACE were investigated using Cox regression models after adjustment for a range of covariates. The BDNF val66met polymorphism modified the associations between vulnerable personality type and worse long-term cardiac outcomes in ACS patients with significant interaction terms, in that the associations were statistically significant in the presence met allele. Similar findings were observed for the individual personality dimensions of agreeableness and neuroticism. Gene (BDNF val66met polymorphism) x environment (personality traits) interactions on long-term cardiac outcomes were found in ACS.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0226802Titel-ID: cdi_plos_journals_2331420911
- Format
- –
- Schlagworte
- Acute Coronary Syndrome - diagnosis, Acute Coronary Syndrome - genetics, Acute Coronary Syndrome - psychology, Acute coronary syndromes, Aged, Angina pectoris, Biology and Life Sciences, Brain-derived neurotrophic factor, Brain-Derived Neurotrophic Factor - genetics, Cardiology, Departments, Environmental factors, Female, Gene polymorphism, Heart, Heart attacks, Humans, Kim, Wan, Male, Medical prognosis, Medical schools, Medicine and Health Sciences, Mental depression, Middle Aged, Neurosis, Neuroticism, Personality, Personality - genetics, Personality Disorders, Personality traits, Polymorphism, Polymorphism, Genetic, Prognosis, Psychiatry, Regression analysis, Regression models, Republic of Korea, Resilience, Psychological, Social Sciences, Statistical analysis, Studies