Details

Autor(en) / Beteiligte

• Correa, Yesenia
• Cabanillas, Billy
• Jullian, Valérie
• Álvarez, Daniela
• Castillo, Denis
• Dufloer, Cédric
• Bustamante, Beatriz
• Roncal, Elisa
• Neyra, Edgar
• Sheen, Patricia
• Sauvain, Michel
• Bach, Horacio

Titel

Identification and characterization of compounds from Chrysosporium multifidum, a fungus with moderate antimicrobial activity isolated from Hermetia illucens gut microbiota

Ist Teil von

• PloS one, 2019-12, Vol.14 (12), p.e0218837-e0218837

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• The gut microbiota of insects is composed of a wide range of microorganisms which produce bioactive compounds that protect their host from pathogenic attack. In the present study, we isolate and identify the fungus Chrysosporium multifidum from the gut of Hermetia illucens larvae. Extract from C. multifidum culture broth supernatant showed moderate activity against a strain of methicillin-resistant Staphylococcus aureus (MRSA). Bioguided isolation of the extract resulted in the characterization of six α-pyrone derivatives (1-6) and one diketopiperazine (7). Of these compounds, 5,6-dihydro-4-methoxy-6-(1-oxopentyl)-2H-pyran-2-one (4) showed the greatest activity (IC50 = 11.4 ± 0.7 μg/mL and MIC = 62.5 μg/mL) against MRSA.