PloS one, 2019-12, Vol.14 (12), p.e0225600-e0225600
2019
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- Autor(en) / Beteiligte
- Titel
- Four months vitamin D supplementation to vitamin D insufficient individuals does not improve muscular strength: A randomized controlled trial
- Ist Teil von
- PloS one, 2019-12, Vol.14 (12), p.e0225600-e0225600
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2019
- Quelle
- EZB-FREE-00999 freely available EZB journals
- Beschreibungen/Notizen
- The inconsistent results on the effects of vitamin D on muscle strength reported by intervention trials may partly be explained by inclusion of vitamin D sufficient individuals. The main objective was to study whether vitamin D supplementation will improve muscle strength in men and women with low serum vitamin D status, as measured by 25-hydroxyvitamin D (25(OH)D) at baseline. 417 men and women aged 40-80 years were included and randomized to receive a loading dose of 100 000 IU (2500 ug) vitamin D3 followed by 20 000 IU (500 ug)/week, or placebo. Muscle strength was tested by dynamometers at baseline and after four months. Serum 25(OH)D levels increased from 32.6±11.1 nmol/l to 88.8±19.4 nmol/l (p<0.01) in the vitamin D group, while remaining low in the placebo group (baseline and final levels at 35.1±13.6 nmol/l and 30.7 ±9.7 nmol/l respectively). Muscle strength (hip flexion, biceps flexion, pectorals and handgrip strength) did not change in any of the groups. The results were the same in analyses stratified on sex, 25(OH)D above/below 25 nmol/L (10 ng/ml); smoking status; and BMI above/below 27 kg/m2. These data does not support vitamin D supplementation for improving muscle strength.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0225600Titel-ID: cdi_plos_journals_2327327636
- Format
- –
- Schlagworte
- 25-Hydroxyvitamin D, Adult, Aged, Aged, 80 and over, Analysis, Biology and Life Sciences, Calciferol, Clinical medicine, Clinical trials, Diabetes, Dietary Supplements, Drug Administration Schedule, Drug dosages, Drug therapy, Dynamometers, Family medical history, Female, Gene expression, Hemoglobin, Hip, Hospitals, Humans, Internal medicine, Male, Medical disciplines: 700, Medicine, Medicine and Health Sciences, Medisinske Fag: 700, Men, Middle Aged, Muscle function, Muscle strength, Muscle Strength - drug effects, Muscle Strength - physiology, Muscle Strength Dynamometer, Muscle, Skeletal - drug effects, Muscle, Skeletal - physiopathology, Musculoskeletal system, Participation, People and Places, Physical sciences, Placebos - administration & dosage, Randomization, Research and Analysis Methods, Smoking, Studies, Supplements, Systematic review, Time Factors, VDP, Vitamin D, Vitamin D - administration & dosage, Vitamin D - analogs & derivatives, Vitamin D - blood, Vitamin D Deficiency - blood, Vitamin D Deficiency - drug therapy, Vitamin D Deficiency - physiopathology, Vitamin D3, Vitamin deficiency, Vitamins, Women, Womens health