Details

Autor(en) / Beteiligte

• Spreizer, Sebastian
• Aertsen, Ad
• Kumar, Arvind
• Doiron, Brent

Titel

From space to time: Spatial inhomogeneities lead to the emergence of spatiotemporal sequences in spiking neuronal networks

Ist Teil von

• PLoS computational biology, 2019-10, Vol.15 (10), p.e1007432-e1007432

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Spatio-temporal sequences of neuronal activity are observed in many brain regions in a variety of tasks and are thought to form the basis of meaningful behavior. However, mechanisms by which a neuronal network can generate spatio-temporal activity sequences have remained obscure. Existing models are biologically untenable because they either require manual embedding of a feedforward network within a random network or supervised learning to train the connectivity of a network to generate sequences. Here, we propose a biologically plausible, generative rule to create spatio-temporal activity sequences in a network of spiking neurons with distance-dependent connectivity. We show that the emergence of spatio-temporal activity sequences requires: (1) individual neurons preferentially project a small fraction of their axons in a specific direction, and (2) the preferential projection direction of neighboring neurons is similar. Thus, an anisotropic but correlated connectivity of neuron groups suffices to generate spatio-temporal activity sequences in an otherwise random neuronal network model.