PloS one, 2019-10, Vol.14 (10), p.e0223070-e0223070
2019
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- Autor(en) / Beteiligte
- Titel
- Alteration of adipose tissue immune cell milieu towards the suppression of inflammation in high fat diet fed mice by flaxseed oil supplementation
- Ist Teil von
- PloS one, 2019-10, Vol.14 (10), p.e0223070-e0223070
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The present study evaluates the effect of flaxseed oil (FXO) supplementation on adipose tissue macrophages (ATM's), E and D series resolvin (Rv) levels and adipose tissue inflammation. Male C57BL/6J mice were divided into five groups (n = 5): lean group (given standard chow diet), HFD group given high fat diet (approx. 18 weeks) till they developed insulin resistance and 4, 8 or 16 mg/kg group (HFD group later orally supplemented with 4, 8 or 16 mg/kg body weight flaxseed oil) for 4 weeks.The present study showed that FXO supplementation led to enhanced DHA, EPA, RvE1-E2, RvD2, RvD5- D6, IL-4, IL-10 and arginase 1 levels in ATMs together with altered immune cell infiltration and reduced NF-κB expression. The FXO supplementation suppresses immune cell infiltration into adipose tissue and alters adipose tissue macrophage phenotype towards the anti-inflammatory state via enhancement of E and D series resolvins, arginase 1 expression and anti-inflammatory cytokines level (IL-4 and IL-10.) leading to amelioration of insulin resistance in flaxseed oil supplemented HFD mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0223070Titel-ID: cdi_plos_journals_2306489135
- Format
- –
- Schlagworte
- Adipose tissue, Adipose Tissue - drug effects, Adipose Tissue - metabolism, Animals, Arginase, Arginase - metabolism, Atherosclerosis, Biochemistry, Biology and Life Sciences, Biosynthesis, Body fat, Body weight, Chemokine CCL2 - metabolism, Cytokines, Cytokines - metabolism, Diabetes, Diet, Diet, High-Fat - adverse effects, Dietary Supplements, Disease Models, Animal, Drug dosages, Fatty acids, Fatty Acids - metabolism, Flaxseed oil, Gene expression, High fat diet, Humans, Immune system, Infiltration, Inflammation, Inflammation - diet therapy, Inflammation - metabolism, Inflammation - pathology, Insulin, Insulin resistance, Insulin Resistance - genetics, Interleukin 10, Interleukin 4, Levels, Linseed Oil - pharmacology, Lipids, Liver diseases, Macrophages, Macrophages - drug effects, Macrophages - metabolism, Male, Medicine and Health Sciences, Metabolism, Mice, NF-κB protein, Obesity, Obesity - diet therapy, Obesity - metabolism, Obesity - pathology, Oils & fats, Oilseeds, Phenotypes, Physiology, Research and Analysis Methods