Details

Autor(en) / Beteiligte

• Dheilly, Nolwenn M
• Ewald, Paul W
• Brindley, Paul J
• Fichorova, Raina N
• Thomas, Frédéric
• Knoll, Laura J.

Titel

Parasite-microbe-host interactions and cancer risk

Ist Teil von

• PLoS pathogens, 2019-08, Vol.15 (8), p.e1007912

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• All viruses that are recognized by the International Agency for Research on Cancer (IARC) as Group 1 carcinogens, namely human papillomaviruses (HPV), Hepatitis B and C viruses (HBV and HCV), Human Herpes Virus type 8 (HHV-8), and Human T-cell lymphotropic virus type 1 (HTLV-1) [2], break barriers to cancer and therefore generate essential causes of their associated cancers [1]. Increasing evidence implicates bacteria (certain strains of Escherichia coli, Fusobacterium nucleatum, Salmonella Typhi, Chlamydia trachomatis, and a range of Mycoplasma) and protists (Cryptosporidum parvum, Trichomonas vaginalis, Trypanosoma cruzi, Toxoplasma gondii) in cancer development [2, 5–26]. Recent studies suggest that microbes and microbial communities can have similar effects: microbiome composition induces a life-history trade-off between life span and reproduction in flies [29]. [...]natural selection will favor establishment of microbes that are either beneficial to the host or present a low cost of infection early in life, even if these microbes promote oncogenesis later in life. [...]focusing on parasites listed above that have been linked to cancer prevalence, virus-like particles have been observed in T. cruzi [76], a dsRNA virus has been found in Cryptosporidium and virus load correlates with parasite fecundity [8, 77], Heterakis gallinarum is a vector of the pathogenic bacterium Histomonas meleagridis [78, 79], Trichuris muris hosts a complex bacterial microbiome [80], Schistosoma mansoni might be a vector of HCV [81], and genome sequencing of Fasciola hepatica revealed the presence of the endobacterium, Neorickettsia [82].