Details

Autor(en) / Beteiligte

• Lee, Dongyeop
• An, Seon Woo A
• Jung, Yoonji
• Yamaoka, Yasuyo
• Ryu, Youngjae
• Goh, Grace Ying Shyen
• Beigi, Arshia
• Yang, Jae-Seong
• Jung, Gyoo Yeol
• Ma, Dengke K
• Ha, Chang Man
• Taubert, Stefan
• Lee, Youngsook
• Lee, Seung-Jae V
• Campisi, Judith

Titel

MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis

Ist Teil von

• PLoS biology, 2019-08, Vol.17 (8), p.e3000415-e3000415

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Low temperatures delay aging and promote longevity in many organisms. However, the metabolic and homeostatic aspects of low-temperature-induced longevity remain poorly understood. Here, we show that lipid homeostasis regulated by Caenorhabditis elegans Mediator 15 (MDT-15 or MED15), a transcriptional coregulator, is essential for low-temperature-induced longevity and proteostasis. We find that inhibition of mdt-15 prevents animals from living long at low temperatures. We show that MDT-15 up-regulates fat-7, a fatty acid desaturase that converts saturated fatty acids (SFAs) to unsaturated fatty acids (UFAs), at low temperatures. We then demonstrate that maintaining a high UFA/SFA ratio is essential for proteostasis at low temperatures. We show that dietary supplementation with a monounsaturated fatty acid, oleic acid (OA), substantially mitigates the short life span and proteotoxicity in mdt-15(-) animals at low temperatures. Thus, lipidostasis regulated by MDT-15 appears to be a limiting factor for proteostasis and longevity at low temperatures. Our findings highlight the crucial roles of lipid regulation in maintaining normal organismal physiology under different environmental conditions.