Details

Autor(en) / Beteiligte

• Lee, Seul-Gee
• Lee, Seung-Jun
• Thuy, Nguyen Viet Phuong
• Kim, Jung-Sun
• Lee, Jung-Jae
• Lee, Oh-Hyun
• Kim, Choong-Ki
• Oh, Jaewon
• Park, Seil
• Lee, Ok-Hee
• Kim, Se Hoon
• Park, Sungha
• Lee, Sang-Hak
• Hong, Sung-Jin
• Ahn, Chul-Min
• Kim, Byeong-Keuk
• Ko, Young-Guk
• Choi, Donghoon
• Hong, Myeong-Ki
• Jang, Yangsoo
• Bader, Michael

Titel

Synergistic protective effects of a statin and an angiotensin receptor blocker for initiation and progression of atherosclerosis

Ist Teil von

• PloS one, 2019-05, Vol.14 (5), p.e0215604-e0215604

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Although the atheroprotective effects of statins and angiotensin II receptor blockers (ARBs) are well-established, little is known about their additive effects, especially during the early period of atherosclerosis. The aim of this study was to investigate whether combination of a statin and an ARB exerts synergistic anti-atherosclerotic effects, and to elucidate the mechanisms of combined effects. Atherosclerotic plaques were developed in arteries of 23 rabbits using a high-cholesterol diet (HCD) and intra-arterial balloon inflation. Rabbits received one of five different treatment strategies for 4 weeks: positive control [n = 5, HCD]; negative control [n = 3, regular chow diet]; statin [n = 5, HCD and rosuvastatin 10 mg]; ARB [n = 5, HCD and olmesartan 20 mg]; and combination [n = 5, HCD and statin+ARB]. Histological analysis demonstrated that development of atherosclerotic plaques was inhibited more in combination group than in statin group (P = 0.001). Although macrophage infiltration identified by RAM11 staining was not significantly different between combination and individual treatment groups (31.76±4.84% [combination] vs. 38.11±6.53% [statin; P = 0.35] or 35.14±2.87% [ARB; P = 0.62]), the relative proportion of pro-inflammatory M1-macrophages was significantly lower in combination group than in ARB group (3.20±0.47% vs. 5.20±0.78%, P = 0.02). Furthermore, M2-macrophage polarization was higher in combination group than in statin group (17.70±3.04% vs. 7.86±0.68%, P = 0.001). Combination treatment with a statin and an ARB produced synergistic protective effects for atherosclerosis initiation and progression, which may be attributed to modulation of macrophage characteristics in the early period of atherosclerosis.