Details
- Autor(en) / Beteiligte
- Titel
- Folate/homocysteine metabolism and lung cancer risk among smokers
- Ist Teil von
- PloS one, 2019-04, Vol.14 (4), p.e0214462
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Folate and homocysteine are involved in DNA synthesis and methylation processes, which are deregulated during carcinogenesis. The aim of this study was to assess the relationship between folate/homocysteine concentrations, the functional polymorphisms of folate/homocysteine genes and lung cancer risk among cigarette smokers. The study included 132 lung cancer patients and 396 controls from northern Poland, matched by sex, age and smoking status. The median cigarette pack-years of smoking among both cases and controls was 30.0. Serum, red blood cell (RBC) folates and serum homocysteine concentrations were measured. The genotypes in selected polymorphic sites of the MTHFR, CBS, SHMT1, MTHFD1, MTRR, MTR, TYMS DHFR, TCN2, and SLC19A1 genes were determined. All study participants underwent scanning with low-dose computed tomography. Serum folate concentrations above the median (> 17.5 nmol/l among the healthy controls) were associated with an increased lung cancer risk (odds ratio [OR], 1.54, 95% confidence intervals [CI], 1.04-2.29, P = 0.031). An analogous trend was observed when the population was analysed after subdivision according to RBC folate concentrations, that is, above a value of 506.5 nmol/l (OR, 1.53; 95% CI, 0.95-2.47; P = 0.084). Additionally, in a subset of women, an increased risk of lung cancer development was associated with the SLC19A1 c.80AA genotype (c.80AA versus GG OR, 3.14; 95% CI, 1.32-7.46; P = P = 0.010). These results suggest that, in the population consisting of heavy smokers, high folate levels add to the cancerogenic effect of smoking.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0214462Titel-ID: cdi_plos_journals_2202615941
- Format
- –
- Schlagworte
- Age Factors, Aged, Biology, Biology and Life Sciences, Blood, Cancer, Cancer genetics, Cancer patients, Cancer research, Carcinogenesis, Carcinogens, CAT scans, Cell growth, Cigarettes, Computed tomography, Confidence intervals, Deoxyribonucleic acid, Deregulation, Dihydrofolate reductase, DNA, DNA biosynthesis, DNA methylation, DNA synthesis, Enzymes, Erythrocytes, Female, Folic acid, Folic Acid - blood, Genes, Genetic aspects, Genetic polymorphisms, Genetic research, Genetics, Genotype, Genotypes, Health aspects, Health risk assessment, Health risks, Homocysteine, Homocysteine - blood, Humans, Lung cancer, Lung diseases, Lung Neoplasms - blood, Lung Neoplasms - diagnosis, Lung Neoplasms - metabolism, Male, Medical research, Medical screening, Medicine and Health Sciences, Metabolism, Metabolites, Methylation, Methylenetetrahydrofolate reductase, Middle Aged, Odds Ratio, Patient outcomes, People and places, Physical Sciences, Poland - epidemiology, Polymorphism, Polymorphism, Single Nucleotide, Radiation therapy, Reduced Folate Carrier Protein - genetics, Reproducibility of Results, Risk, Risk Factors, Sex Factors, Smokers, Smoking, Smoking - adverse effects, Social Sciences, Thoracic surgery, Tomography, Vitamin B