PloS one, 2019-01, Vol.14 (1), p.e0209010-e0209010
2019
Details
- Autor(en) / Beteiligte
- Titel
- Genetic variants in genes related to inflammation, apoptosis and autophagy in breast cancer risk
- Ist Teil von
- PloS one, 2019-01, Vol.14 (1), p.e0209010-e0209010
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Inflammation contributes to breast cancer development through its effects on cell damage. This damage is usually dealt with by key genes involved in apoptosis and autophagy pathways. We tested 206 single nucleotide polymorphisms (SNPs) in 54 genes related to inflammation, apoptosis and autophagy in a population-based breast cancer study of women of European (658 cases and 795 controls) and East Asian (262 cases and 127 controls) descent. Logistic regression was used to estimate odds ratios for breast cancer risk, and case-only analysis to compare breast cancer subtypes (defined by ER/PR/HER2 status), with adjustment for confounders. We assessed statistical interactions between the SNPs and lifestyle factors (smoking status, physical activity and body mass index). Although no SNP was associated with breast cancer risk among women of European descent, we found evidence for an association among East Asians for rs1800925 (IL-13) and breast cancer risk (OR = 2.08; 95% CI: 1.32-3.28; p = 0.000779), which remained statistically significant after multiple testing correction (padj = 0.0350). This association was replicated in a meta-analysis of 4305 cases and 4194 controls in the Shanghai Breast Cancer Genetics Study (OR 1.12, 95% CI: 1.03-1.21, p = 0.011). Further, we found evidence of an interaction between rs7874234 (TSC1) and physical activity among women of East Asian descent.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0209010Titel-ID: cdi_plos_journals_2162764937
- Format
- –
- Schlagworte
- Adult, Apoptosis, Apoptosis - genetics, Apoptosis - physiology, Autophagy, Autophagy (Cytology), Autophagy - genetics, Autophagy - physiology, Biology and Life Sciences, Body mass, Body mass index, Body size, Breast cancer, Breast Neoplasms - genetics, Cancer, Cell death, Descent, Development and progression, Epidemiology, ErbB-2 protein, Exercise, Female, Genes, Genetic aspects, Genetic diversity, Genetic Predisposition to Disease - genetics, Genetic variance, Genetics, Genome-Wide Association Study, Genomes, Health care, Health risk assessment, Health risks, Health sciences, Hormone replacement therapy, Humans, Inflammation, Inflammation - genetics, Interleukin 13, Internet, Lifestyles, Logistic Models, Mammography, Medical prognosis, Medical research, Medicine and Health Sciences, Middle Aged, Mutation, Odds Ratio, People and Places, Phagocytosis, Physical activity, Polymorphism, Single Nucleotide - genetics, Population, Population (statistical), Population studies, Preventive medicine, Public health, Receptors, Estrogen - genetics, Receptors, Progesterone - genetics, Regression analysis, Risk analysis, Risk factors, Single nucleotide polymorphisms, Single-nucleotide polymorphism, Smoking, Statistical analysis, Studies, Tuberous Sclerosis Complex 1, Womens health, Young Adult