PloS one, 2018-08, Vol.13 (8), p.e0202532-e0202532
2018
Details
- Autor(en) / Beteiligte
- Titel
- Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats
- Ist Teil von
- PloS one, 2018-08, Vol.13 (8), p.e0202532-e0202532
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- After peripheral nerve crush injury, the fibers of distal nerve segments gradually disintegrate, and axons regrow from the proximal nerve segment, eventually reaching the target organ. However, the axon regeneration is generally not sufficient for the recovery of neurological function, so drug therapy is necessary. In the current study, we explored the effect of Tanshinone IIA in nerve regeneration in a sciatic nerve crush injury model using Sprague Dawley rats. The rats were administered 45 mg/kg of Tanshinone IIA once daily. Motor behavior and tibialis anterior muscle mass were assessed, and histological analysis of the sciatic nerve and lumbar spinal cord were conducted. The results showed that the administration of Tanshinone IIA improved nerve growth and motor function, and resulted in a marked decrease of neuronal death. The findings of this exploratory study suggest that Tanshinone IIA alleviates injury and boosts regeneration after nerve crush injury in a rat model of sciatic nerve injury.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0202532Titel-ID: cdi_plos_journals_2092586997
- Format
- –
- Schlagworte
- Analysis, Animals, Axon guidance, Axons, Biology and Life Sciences, Cell Death - drug effects, Crush Injuries - drug therapy, Crush Injuries - physiopathology, Crushing, Diterpenes, Abietane - administration & dosage, Drug therapy, Embryology, Growth factors, Health aspects, Herbal medicine, Humans, Injuries, Ischemia, Laboratory animals, Medical research, Medicine and Health Sciences, Motor task performance, Muscles, Nerve Crush, Nerve Regeneration - drug effects, Nerves, Peripheral, Neurons - drug effects, Neurons - pathology, Orthopedics, Peripheral nerve diseases, Peripheral nerves, Peripheral nervous system diseases, Polypeptides, Quality of life, Rats, Rattus, Regeneration, Researchers, Rodents, Schwann cells, Sciatic nerve, Sciatic Nerve - drug effects, Sciatic Nerve - growth & development, Sciatic Nerve - injuries, Sciatic Nerve - physiopathology, Skeletal muscle, Spinal cord, Structure-function relationships, Studies, Tibialis anterior muscle, Trauma