Details

Autor(en) / Beteiligte

• Ostuzzi, Giovanni
• Mazzi, Maria Angela
• Terlizzi, Samira
• Bertolini, Federico
• Aguglia, Andrea
• Bartoli, Francesco
• Bortolaso, Paola
• Callegari, Camilla
• Caroleo, Mariarita
• Carrà, Giuseppe
• Corbo, Mariangela
• D'Agostino, Armando
• Gastaldon, Chiara
• Lucii, Claudio
• Magliocco, Fabio
• Martinotti, Giovanni
• Nosé, Michela
• Ostinelli, Edoardo Giuseppe
• Papola, Davide
• Piccinelli, Marco Piero
• Piccoli, Alberto
• Purgato, Marianna
• Tabacchi, Tommaso
• Turrini, Giulia
• Ruggeri, Mirella
• Barbui, Corrado
• Mazza, Marianna

Titel

Factors associated with first- versus second-generation long-acting antipsychotics prescribed under ordinary clinical practice in Italy

Ist Teil von

• PloS one, 2018-08, Vol.13 (8), p.e0201371

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• For many years, long-acting intramuscular (LAI) antipsychotics have been prescribed predominantly to chronic and severe patients, as a last resort when other treatments failed. Recently, a broader and earlier use of LAIs, particularly second-generation LAIs, has been emphasized. To date, few studies attempted to frame how this change in prescribing took place in real-world practice. Therefore, this study aimed to describe the clinical features of patients prescribed with LAIs, and to explore possible prescribing differences between first- and second-generations LAIs under ordinary clinical practice in Italy. The STAR Network "Depot" Study is an observational, longitudinal, multicenter study involving 35 centers in Italy. In the cross-sectional phase, patients prescribed with LAIs were consecutively recruited and assessed over a period of 12 months. Descriptive statistics and multivariable logistic regression analyses were employed. Of the 451 recruited patients, 61% were males. The level of social and working functioning was heterogeneous, as was the severity of disease. Seventy-two per cent of the patients had a diagnosis of the schizophrenia spectrum. Seventy per cent were prescribed with second-generation antipsychotic (SGA) LAIs (mostly paliperidone, aripiprazole and risperidone). Compared to first-generation antipsychotic (FGA) LAIs, patients prescribed with SGA LAIs were more often younger; employed; with a diagnosis of the schizophrenia spectrum or bipolar disorder; with higher levels of affective symptoms; with fewer LAI prescriptions in the past. LAIs' prescribing practices appear to be more flexible as compared to the past, although this change is mostly restricted to SGA LAIs.