Effect of phenolic extracts from different extra-virgin olive oil varieties on osteoblast-like cells
2018
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- Autor(en) / Beteiligte
- Titel
- Effect of phenolic extracts from different extra-virgin olive oil varieties on osteoblast-like cells
- Ist Teil von
- PloS one, 2018-04, Vol.13 (4), p.e0196530-e0196530
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2018
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The reported incidence of osteoporosis is lower in countries in which the Mediterranean diet predominates, and this apparent relationship may be mediated by the phenolic compounds present in olive oil. The objective of this study was to determine the effect of phenolic extracts from different varieties of extra-virgin olive oil (Picual, Arbequina, Picudo, and Hojiblanca) on the differentiation, antigenic expression, and phagocytic capacity of osteoblast-like MG-63 cells. At 24 h of treatment a significant increase in phosphatase alkaline activity and significant reductions in CD54, CD80, and HLA-DR expression and in phagocytic activity were observed in comparison to untreated controls. The in vitro study performed has demonstrated that phenolic compounds from different extra virgin olive oil varieties can modulate different parameters related to osteoblast differentiation and function.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0196530Titel-ID: cdi_plos_journals_2031410862
- Format
- –
- Schlagworte
- Alkaline Phosphatase - metabolism, Analysis, Antigens, Biocompatibility, Biology and Life Sciences, Biomedical materials, Bone cancer, CD80 antigen, Cell growth, Cell Line, Cytokines, Diet, Differentiation, Genotype & phenotype, Growth factors, Health aspects, Health sciences, Histocompatibility antigen HLA, HLA-DR Antigens - metabolism, Humans, Intercellular Adhesion Molecule-1 - metabolism, Medicine and Health Sciences, Mediterranean diet, Nursing, Oils & fats, Olea - chemistry, Olea - metabolism, Olive oil, Olives, Osteoblastogenesis, Osteoblasts - cytology, Osteoblasts - drug effects, Osteoblasts - metabolism, Osteoporosis, Oxidative stress, Phagocytes, Phagocytosis - drug effects, Phenolic compounds, Phenols, Phenols - chemistry, Phosphatases, Physical Sciences, Plant Extracts - pharmacology, Polyphenols