PloS one, 2014-08, Vol.9 (8), p.e104616-e104616
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis
- Ist Teil von
- PloS one, 2014-08, Vol.9 (8), p.e104616-e104616
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2014
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. Therefore, Icariin might be applied in treatment of neurodegenerative disorders, including Alzheimer's disease (AD), which is neuropathologically characterized by β-amyloid aggregation, hyperphosphorylated tau and neuroinflammation. Potential therapeutic effects of Icariin were investigated in an animal model of cerebral amyloidosis for AD, transgenic APP/PS1 mouse. Icariin was suspended in carboxymethylcellulose and given orally to APP/PS1 mice. Therapeutic effects were monitored by behavioral tests, namely nesting assay, before and during the experimental treatment. Following an oral treatment of 10 days, Icariin significantly attenuated Aβ deposition, microglial activation and TGF-β1 immunoreactivity at amyloid plaques in cortex and hippocampus of transgenic mice 5 months of age, and restored impaired nesting ability. Our results suggest that Icariin might be considered a promising therapeutic option for human AD.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0104616Titel-ID: cdi_plos_journals_2014070556
- Format
- –
- Schlagworte
- Age, Alzheimer Disease - drug therapy, Alzheimer Disease - genetics, Alzheimer Disease - metabolism, Alzheimer Disease - pathology, Alzheimer's disease, Alzheimers disease, Amyloid beta-Protein Precursor - biosynthesis, Amyloid beta-Protein Precursor - genetics, Amyloidosis, Animal cognition, Animals, Behavior, Animal - drug effects, Biological properties, Biology and Life Sciences, Brain, Carboxymethylcellulose, Cognitive ability, Disease Models, Animal, Female, Flavonoids, Flavonoids - pharmacology, Growth factors, Herbal medicine, Humans, Immunoreactivity, Inflammation, Males, Medical treatment, Medicinal plants, Medicine and Health Sciences, Memory, Mice, Mice, Transgenic, Nervous system, Nesting, Neurodegeneration, Neurodegenerative diseases, Neuropathology, Neuroprotection, Pathology, Presenilin 1, Proteins, Rodents, Senile plaques, Stroke, Tau protein, Transforming Growth Factor beta1 - genetics, Transforming Growth Factor beta1 - metabolism, Transforming growth factor-b1, Transgenic animals, Transgenic mice, β-Amyloid