PLoS pathogens, 2018-01, Vol.14 (1), p.e1006796-e1006796
2018
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Details
- Autor(en) / Beteiligte
- Titel
- Influenza A virus hemagglutinin glycosylation compensates for antibody escape fitness costs
- Ist Teil von
- PLoS pathogens, 2018-01, Vol.14 (1), p.e1006796-e1006796
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Rapid antigenic evolution enables the persistence of seasonal influenza A and B viruses in human populations despite widespread herd immunity. Understanding viral mechanisms that enable antigenic evolution is critical for designing durable vaccines and therapeutics. Here, we utilize the primerID method of error-correcting viral population sequencing to reveal an unexpected role for hemagglutinin (HA) glycosylation in compensating for fitness defects resulting from escape from anti-HA neutralizing antibodies. Antibody-free propagation following antigenic escape rapidly selected viruses with mutations that modulated receptor binding avidity through the addition of N-linked glycans to the HA globular domain. These findings expand our understanding of the viral mechanisms that maintain fitness during antigenic evolution to include glycan addition, and highlight the immense power of high-definition virus population sequencing to reveal novel viral adaptive mechanisms.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1553-7374, 1553-7366eISSN: 1553-7374DOI: 10.1371/journal.ppat.1006796Titel-ID: cdi_plos_journals_2002619100
- Format
- –
- Schlagworte
- Analysis, Animals, Antibodies, Antibodies, Viral - immunology, Antibodies, Viral - metabolism, Antigenic Variation - genetics, Antigens, Avidity, Bioinformatics, Biology and life sciences, Cellular biology, Costs, Dogs, Drug resistance, Error correction, Evolution, Fitness, Genetic Fitness, Glycan, Glycosylation, HEK293 Cells, Hemagglutination tests, Hemagglutinin Glycoproteins, Influenza Virus - immunology, Hemagglutinin Glycoproteins, Influenza Virus - metabolism, Hemagglutinins, Herd immunity, Human populations, Humans, Immune Evasion - genetics, Immune Evasion - immunology, Immunity, Immunoglobulins, Influenza, Influenza A, Influenza A Virus, H1N1 Subtype - immunology, Influenza A Virus, H1N1 Subtype - metabolism, Influenza Vaccines - immunology, Influenza viruses, Laboratories, Madin Darby Canine Kidney Cells, Medicine and health sciences, Mutation, N-glycans, Physical Sciences, Polysaccharides, Population, Protein Processing, Post-Translational - physiology, Proteins, Reproductive fitness, Software, Supervision, Vaccines, Viruses