Details

Autor(en) / Beteiligte

• Urosa, Aitor
• Tobal, Ignacio E
• de la Granja, Ángela P
• Capitán, M Carmen
• Moro, R F
• Marcos, Isidro S
• Garrido, Narciso M
• Sanz, Francisca
• Calle, Emilio
• Díez, David
• Marr, Andrew C.

Titel

Diastereoselective synthesis of chiral 1,3-cyclohexadienals

Ist Teil von

• PloS one, 2018-02, Vol.13 (2), p.e0192113-e0192113

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2018

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A novel approach to the production of chiral 1,3-cyclohexadienals has been developed. The organocatalysed asymmetric reaction of different β-disubstituted-α,β-unsaturated aldehydes with a chiral α,β-unsaturated aldehyde in the presence of a Jørgensen-Hayashi organocatalyst provides easy and stereocontrolled access to the cyclohexadienal backbone. This method allows for the synthesis of potential photoprotective chiral 1,3-cyclohexadienals and extra extended conjugation compounds in a simple manner.