Details

Autor(en) / Beteiligte

• Lavtar, Polona
• Rudolf, Gorazd
• Maver, Aleš
• Hodžić, Alenka
• Starčević Čizmarević, Nada
• Živković, Maja
• Šega Jazbec, Saša
• Klemenc Ketiš, Zalika
• Kapović, Miljenko
• Dinčić, Evica
• Raičević, Ranko
• Sepčić, Juraj
• Lovrečić, Luca
• Stanković, Aleksandra
• Ristić, Smiljana
• Peterlin, Borut
• Yamazaki, Shin

Titel

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis

Ist Teil von

• PloS one, 2018-01, Vol.13 (1), p.e0190601-e0190601

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.5·10-5; CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35-2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13-1.73, P = 0.002). The results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis.