PLoS pathogens, 2017-11, Vol.13 (11), p.e1006703-e1006703
2017
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- Autor(en) / Beteiligte
- Titel
- Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1
- Ist Teil von
- PLoS pathogens, 2017-11, Vol.13 (11), p.e1006703-e1006703
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Host genetic variation modifying HIV-1 acquisition risk can inform development of HIV-1 prevention strategies. However, associations between rare or intermediate-frequency variants and HIV-1 acquisition are not well studied. We tested for the association between variation in genic regions and extreme HIV-1 acquisition phenotypes in 100 sub-Saharan Africans with whole genome sequencing data. Missense variants in immunoglobulin-like regions of CD101 and, among women, one missense/5' UTR variant in UBE2V1, were associated with increased HIV-1 acquisition risk (p = 1.9x10-4 and p = 3.7x10-3, respectively, for replication). Both of these genes are known to impact host inflammatory pathways. Effect sizes increased with exposure to HIV-1 after adjusting for the independent effect of increasing exposure on acquisition risk. ClinicalTrials.gov NCT00194519; NCT00557245.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1553-7374, 1553-7366eISSN: 1553-7374DOI: 10.1371/journal.ppat.1006703Titel-ID: cdi_plos_journals_1977641526
- Format
- –
- Schlagworte
- Acquired immune deficiency syndrome, African Continental Ancestry Group, AIDS, Antigens, CD - genetics, Biology and Life Sciences, Clinical trials, Disease prevention, Disease transmission, Epidemiology, Exposure, Funding, Gene sequencing, Genes, Genetic diversity, Genetic Predisposition to Disease, Genetic Variation - genetics, Genome-Wide Association Study, Genomes, Health risks, HIV, HIV Infections - genetics, HIV Infections - transmission, HIV-1 - genetics, Human immunodeficiency virus, Humans, Infections, Inflammation, Medical research, Medicine, Medicine and Health Sciences, Membrane Glycoproteins - genetics, Pediatrics, People and Places, Phenotype, Polymorphism, Single Nucleotide - genetics, Public health, R&D, Research & development, Risk, Sexual Behavior, Sexually transmitted diseases, Software, STD, Supervision, Transcription Factors - genetics, Ubiquitin-Conjugating Enzymes - genetics, Vaccines, Whole Genome Sequencing