Details

Autor(en) / Beteiligte

• Paternoster, Lavinia
• Tilling, Kate
• Davey Smith, George
• Barsh, Gregory S.

Titel

Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges

Ist Teil von

• PLoS genetics, 2017-10, Vol.13 (10), p.e1006944-e1006944

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• The past decade has been proclaimed as a hugely successful era of gene discovery through the high yields of many genome-wide association studies (GWAS). However, much of the perceived benefit of such discoveries lies in the promise that the identification of genes that influence disease would directly translate into the identification of potential therapeutic targets, but this has yet to be realized at a level reflecting expectation. One reason for this, we suggest, is that GWAS, to date, have generally not focused on phenotypes that directly relate to the progression of disease and thus speak to disease treatment.