Details

Autor(en) / Beteiligte

• Stroo, Ingrid
• Yang, Jack
• Anas, Adam A
• de Boer, J Daan
• van Mierlo, Gerard
• Roem, Dorina
• Wouters, Diana
• Engel, Ruchira
• Roelofs, Joris J T H
• van 't Veer, Cornelis
• van der Poll, Tom
• Zeerleder, Sacha
• Ryffel, Bernhard

Titel

Human plasma-derived C1 esterase inhibitor concentrate has limited effect on house dust mite-induced allergic lung inflammation in mice

Ist Teil von

• PloS one, 2017-10, Vol.12 (10), p.e0186652-e0186652

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma. We explored the effect of human plasma-derived C1-INH on allergic lung inflammation in a house dust mite (HDM) induced asthma mouse model by daily administration of C1-INH (15 U) during the challenge phase. NaCl and HDM exposed mice had comparable plasma C1-INH levels, while bronchoalveolar lavage fluid (BALF) levels were increased in HDM exposed mice coinciding with slightly reduced activation of complement (C5a). C1-INH treatment reduced Th2 response and enhanced HDM-specific IgG1. Influx of eosinophils in BALF or lung, pulmonary damage, mucus production, procoagulant response or plasma leakage in BALF was similar in both groups. In conclusion, C1-INH dampens Th2 responses during HDM induced allergic lung inflammation.