PloS one, 2017-09, Vol.12 (9), p.e0184928
2017
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- Autor(en) / Beteiligte
- Titel
- A nonrandomized trial of vitamin D supplementation for Barrett's esophagus
- Ist Teil von
- PloS one, 2017-09, Vol.12 (9), p.e0184928
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Vitamin D deficiency may increase esophageal cancer risk. Vitamin D affects genes regulating proliferation, apoptosis, and differentiation and induces the tumor suppressor 15-hydroxyprostaglandin dehydrogenase (PGDH) in other cancers. This nonrandomized interventional study assessed effects of vitamin D supplementation in Barrett's esophagus (BE). We hypothesized that vitamin D supplementation may have beneficial effects on gene expression including 15-PGDH in BE. BE subjects with low grade or no dysplasia received vitamin D3 (cholecalciferol) 50,000 international units weekly plus a proton pump inhibitor for 12 weeks. Esophageal biopsies from normal plus metaplastic BE epithelium and blood samples were obtained before and after vitamin D supplementation. Serum 25-hydroxyvitamin D was measured to characterize vitamin D status. Esophageal gene expression was assessed using microarrays. 18 study subjects were evaluated. The baseline mean serum 25-hydroxyvitamin D level was 27 ng/mL (normal ≥30 ng/mL). After vitamin D supplementation, 25-hydroxyvitamin D levels rose significantly (median increase of 31.6 ng/mL, p<0.001). There were no significant changes in gene expression from esophageal squamous or Barrett's epithelium including 15-PGDH after supplementation. BE subjects were vitamin D insufficient. Despite improved vitamin D status with supplementation, no significant alterations in gene expression profiles were noted. If vitamin D supplementation benefits BE, a longer duration or higher dose of supplementation may be needed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0184928Titel-ID: cdi_plos_journals_1940194133
- Format
- –
- Schlagworte
- 15-Hydroxyprostaglandin dehydrogenase (NAD+), 25-Hydroxyvitamin D, Aged, Apoptosis, Barrett esophagus, Barrett Esophagus - drug therapy, Barrett Esophagus - enzymology, Barrett Esophagus - pathology, Biology and Life Sciences, Cancer, Cholecalciferol - blood, Colorectal cancer, Complications and side effects, Diet therapy, Differentiation, DNA microarrays, Dosage and administration, Dysplasia, Epithelium, Esophageal cancer, Esophagus, Female, Gastroenterology, Gene expression, Gene Expression Regulation, Enzymologic - drug effects, Genetic aspects, Health risk assessment, Health risks, Hospitals, Humans, Hydroxyprostaglandin Dehydrogenases - biosynthesis, Male, Medical prognosis, Medicine, Medicine and Health Sciences, Middle Aged, Pathology, Patient outcomes, Physical sciences, Pilot Projects, Proton pump inhibitors, Proton Pump Inhibitors - administration & dosage, Proton Pump Inhibitors - pharmacokinetics, Quality, Supplementation, Supplements, Tumor suppressor genes, Veterans, Vitamin D, Vitamin D - administration & dosage, Vitamin D - pharmacokinetics, Vitamin D3, Vitamin deficiency