Details

Autor(en) / Beteiligte

• Styczynski, Ashley R
• Malta, Juliane M A S
• Krow-Lucal, Elisabeth R
• Percio, Jadher
• Nóbrega, Martha E
• Vargas, Alexander
• Lanzieri, Tatiana M
• Leite, Priscila L
• Staples, J Erin
• Fischer, Marc X
• Powers, Ann M
• Chang, Gwong-Jen J
• Burns, P L
• Borland, Erin M
• Ledermann, Jeremy P
• Mossel, Eric C
• Schonberger, Lawrence B
• Belay, Ermias B
• Salinas, Jorge L
• Badaro, Roberto D
• Sejvar, James J
• Coelho, Giovanini E
• Carvalho, Marilia Sá

Titel

Increased rates of Guillain-Barré syndrome associated with Zika virus outbreak in the Salvador metropolitan area, Brazil

Ist Teil von

• PLoS neglected tropical diseases, 2017-08, Vol.11 (8), p.e0005869-e0005869

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• In mid-2015, Salvador, Brazil, reported an outbreak of Guillain-Barré syndrome (GBS), coinciding with the introduction and spread of Zika virus (ZIKV). We found that GBS incidence during April-July 2015 among those ≥12 years of age was 5.6 cases/100,000 population/year and increased markedly with increasing age to 14.7 among those ≥60 years of age. We conducted interviews with 41 case-patients and 85 neighborhood controls and found no differences in demographics or exposures prior to GBS-symptom onset. A higher proportion of case-patients (83%) compared to controls (21%) reported an antecedent illness (OR 18.1, CI 6.9-47.5), most commonly characterized by rash, headache, fever, and myalgias, within a median of 8 days prior to GBS onset. Our investigation confirmed an outbreak of GBS, particularly in older adults, that was strongly associated with Zika-like illness and geo-temporally associated with ZIKV transmission, suggesting that ZIKV may result in severe neurologic complications.