PloS one, 2017-06, Vol.12 (6), p.e0175790
2017
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- Autor(en) / Beteiligte
- Titel
- Serum proteins mediate depression's association with dementia
- Ist Teil von
- PloS one, 2017-06, Vol.12 (6), p.e0175790
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2017
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The latent variable "δ" (for "dementia") uniquely explains dementia severity. Depressive symptoms are independent predictors of δ. We explored 115 serum proteins as potential causal mediators of the effect of depressive symptoms on δ in a large, ethnically diverse, longitudinal cohort. All models were adjusted for age, apolipoprotein E, education, ethnicity, gender, hemoglobin A1c, and homocysteine, and replicated in randomly selected 50% subsets. Alpha1-antitrypsin (A1AT), FAS, Heparin-binding EGF-like Growth Factor (HB-EGF), Insulin-like Growth Factor-1 (IGF-1), Luteinizing Hormone (LH), Macrophage Inflammatory Protein type 1 alpha (MIP-1α), Resitin, S100b, Tissue Inhibitor of Metalloproteinase type 1 (TIMP-1), and Vascular Cell Adhesion Molecule type 1 (VCAM-1) each were partial mediators of depression's association with δ. These proteins may offer targets for the treatment of depression's specific effect on dementia severity and Alzheimer's Disease (AD) conversion risk.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0175790Titel-ID: cdi_plos_journals_1907553346
- Format
- –
- Schlagworte
- Activities of daily living, Age, Aged, Alzheimer's disease, Apolipoprotein E, Binding, Biology and Life Sciences, Biomarkers, Biomarkers - blood, Blood Proteins - metabolism, Care and treatment, Cell adhesion, Cell adhesion molecules, Chronic obstructive pulmonary disease, Cognitive ability, Conversion, Dementia, Dementia - blood, Dementia - complications, Dementia disorders, Depression (Mood disorder), Depression - blood, Depression - complications, Education, Fas antigen, Gender, Genetic aspects, Hemoglobin, Heparin, Homocysteine, Humans, Inflammation, Inhibitors, Insulin, Insulin-like growth factor I, Intelligence, Luteinizing hormone, Macrophage inflammatory protein, Macrophages, Mathematical models, Medicine and Health Sciences, Memory, Mental depression, Metalloproteinase, Minority & ethnic groups, Neurodegenerative diseases, People and Places, Physiological aspects, Properties, Proteins, Psychiatry, Resistin - blood, Risk factors, S100b protein, Science, Serum proteins, Tissue inhibitor of metalloproteinase 1