Details

Autor(en) / Beteiligte

• Bashir, Ali
• Attie, Oliver
• Sullivan, Mitchell
• Sebra, Robert
• Singh, Kavindra V
• Altman, Deena
• Pak, Theodore
• Dutta, Jayeeta
• Chacko, Kieran
• Webster, Elizabeth
• Lewis, Martha
• Hamula, Camille
• Delli Carpini, Kristin W
• Murray, Barbara E
• Kasarskis, Andrew
• van Bakel, Harm
• Huprikar, Shirish
• Nübel, Ulrich

Titel

Genomic confirmation of vancomycin-resistant Enterococcus transmission from deceased donor to liver transplant recipient

Ist Teil von

• PloS one, 2017-03, Vol.12 (3), p.e0170449-e0170449

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• In a liver transplant recipient with vancomycin-resistant Enterococcus (VRE) surgical site and bloodstream infection, a combination of pulsed-field gel electrophoresis, multilocus sequence typing, and whole genome sequencing identified that donor and recipient VRE isolates were highly similar when compared to time-matched hospital isolates. Comparison of de novo assembled isolate genomes was highly suggestive of transplant transmission rather than hospital-acquired transmission and also identified subtle internal rearrangements between donor and recipient missed by other genomic approaches. Given the improved resolution, whole-genome assembly of pathogen genomes is likely to become an essential tool for investigation of potential organ transplant transmissions.