PloS one, 2017-03, Vol.12 (3), p.e0173373-e0173373
2017
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- Autor(en) / Beteiligte
- Titel
- Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle
- Ist Teil von
- PloS one, 2017-03, Vol.12 (3), p.e0173373-e0173373
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2017
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Gestational diabetes mellitus (GDM), which complicates up to 20% of all pregnancies, is associated with low-grade maternal inflammation and peripheral insulin resistance. Sterile inflammation and infection are key mediators of this inflammation and peripheral insulin resistance. Resveratrol, a stilbene-type phytophenol, has been implicated to exert beneficial properties including potent anti-inflammatory and antidiabetic effects in non-pregnant humans and experimental animal models of GDM. However, studies showing the effects of resveratrol on inflammation and insulin resistance associated with GDM in human tissues have been limited. In this study, human placenta, adipose (omental and subcutaneous) tissue and skeletal muscle were stimulated with pro-inflammatory cytokines TNF-α and IL-1β, the bacterial product lipopolysaccharide (LPS) and the synthetic viral dsRNA analogue polyinosinic:polycytidylic acid (poly(I:C)) to induce a GDM-like model. Treatment with resveratrol significantly reduced the expression and secretion of pro-inflammatory cytokines IL-6, IL-1α, IL-1β and pro-inflammatory chemokines IL-8 and MCP-1 in human placenta and omental and subcutaneous adipose tissue. Resveratrol also significantly restored the defects in the insulin signalling pathway and glucose uptake induced by TNF-α, LPS and poly(I:C). Collectively, these findings suggest that resveratrol reduces inflammation and insulin resistance induced by chemical and microbial products. Resveratrol may be a useful preventative therapeutic for pregnancies complicated by inflammation and insulin resistance, like GDM.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0173373Titel-ID: cdi_plos_journals_1875828554
- Format
- –
- Schlagworte
- Adipose tissue, Adipose Tissue - drug effects, Adipose Tissue - metabolism, Adipose Tissue - microbiology, Adipose Tissue - pathology, Adipose tissues, Analysis, Animal models, Bacteria, Biology and Life Sciences, Body fat, Chemokines, Cytokines, Dextrose, Diabetes, Diabetes mellitus, Diabetes, Gestational - metabolism, Diabetes, Gestational - microbiology, Diabetes, Gestational - pathology, Disease, Dosage and administration, Double-stranded RNA, Drug resistance in microorganisms, Endocrinology, Fatty acids, Female, Glucose, Glucose metabolism, Gynecology, Health aspects, Hospitals, Human tissues, Humans, Infant, Inflammation, Inflammation - metabolism, Inflammation - microbiology, Insulin, Insulin - metabolism, Insulin Resistance, Interleukin 6, Interleukin 8, Ligands, Lipopolysaccharides, Medicine and Health Sciences, Metabolism, Microbial drug resistance, Microorganisms, Mitogens, Monocyte chemoattractant protein 1, Muscle, Skeletal - drug effects, Muscle, Skeletal - metabolism, Muscle, Skeletal - microbiology, Muscle, Skeletal - pathology, Muscles, Musculoskeletal system, Nutrition research, Obesity, Obstetrics, Physiological aspects, Placenta, Placenta - drug effects, Placenta - metabolism, Placenta - microbiology, Placenta - pathology, Poly (I:C), Polyinosinic:polycytidylic acid, Preeclampsia, Pregnancy, Pregnant women, Research and Analysis Methods, Resveratrol, Rodents, Signal transduction, Signal Transduction - drug effects, Signaling, Skeletal muscle, Stilbene, Stilbenes - pharmacology, Tissues, Tumor necrosis factor-α, Womens health