Details

Autor(en) / Beteiligte

• Hulo, Chantal
• Masson, Patrick
• de Castro, Edouard
• Auchincloss, Andrea H
• Foulger, Rebecca
• Poux, Sylvain
• Lomax, Jane
• Bougueleret, Lydie
• Xenarios, Ioannis
• Le Mercier, Philippe
• Alvisi, Gualtiero

Titel

The ins and outs of eukaryotic viruses: Knowledge base and ontology of a viral infection

Ist Teil von

• PloS one, 2017-02, Vol.12 (2), p.e0171746-e0171746

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Viruses are genetically diverse, infect a wide range of tissues and host cells and follow unique processes for replicating themselves. All these processes were investigated and indexed in ViralZone knowledge base. To facilitate standardizing data, a simple ontology of viral life-cycle terms was developed to provide a common vocabulary for annotating data sets. New terminology was developed to address unique viral replication cycle processes, and existing terminology was modified and adapted. The virus life-cycle is classically described by schematic pictures. Using this ontology, it can be represented by a combination of successive terms: "entry", "latency", "transcription", "replication" and "exit". Each of these parts is broken down into discrete steps. For example Zika virus "entry" is broken down in successive steps: "Attachment", "Apoptotic mimicry", "Viral endocytosis/ macropinocytosis", "Fusion with host endosomal membrane", "Viral factory". To demonstrate the utility of a standard ontology for virus biology, this work was completed by annotating virus data in the ViralZone, UniProtKB and Gene Ontology databases.