PloS one, 2017-01, Vol.12 (1), p.e0169922-e0169922
2017
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Details
- Autor(en) / Beteiligte
- Titel
- IL-37 Confers Protection against Mycobacterial Infection Involving Suppressing Inflammation and Modulating T Cell Activation
- Ist Teil von
- PloS one, 2017-01, Vol.12 (1), p.e0169922-e0169922
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2017
- Quelle
- Elektronische Zeitschriftenbibliothek (Open access)
- Beschreibungen/Notizen
- Interleukin-37 (IL-37), a novel member of the IL-1 family, plays fundamental immunosuppressive roles by broadly reducing both innate inflammation and acquired immunity, but whether it is involved in the pathogenesis of tuberculosis (TB) has not been clearly elucidated. In this study, single nucleotide polymorphism (SNP) analysis demonstrated an association of the genetic variant rs3811047 of IL-37 with TB susceptibility. In line with previous report, a significant elevated IL-37 abundance in the sera and increased expression of IL-37 protein in the peripheral blood mononuclear cells (PBMC) were observed in TB patients in comparison to healthy controls. Moreover, release of IL-37 were detected in either macrophages infected with Mycobacterium tuberculosis (Mtb) or the lung of BCG-infected mice, concurrent with reduced production of proinflammatory cytokines including IL-6 and TNF-α. Furthermore, in contrast to wild-type mice, BCG-infected IL-37-Tg mice manifested with reduced mycobacterial burden and tissue damage in the lung, accompanied by higher frequency of Th1 cell and less frequencies of regulatory T cells and Th17 cells in the spleen. Taken together, our findings demonstrated that IL-37 conferred resistance to Mtb infection possibly involving suppressing detrimental inflammation and modulating T cell responses. These findings implicated that IL-37 may be employed as a new molecular target for the therapy and diagnosis of TB.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0169922Titel-ID: cdi_plos_journals_1857739601
- Format
- –
- Schlagworte
- Animals, Bacillus Calmette-Guerin vaccine, Bacterial infections, BCG, Biology and Life Sciences, Case-Control Studies, Cell activation, Cells, Cultured, Cytokines, Cytoprotection - genetics, Cytoprotection - immunology, Female, Gene Frequency, Gene polymorphism, Genetic diversity, Genetic Predisposition to Disease, Genetic variance, Health aspects, Health care, Helper cells, Humans, Immunity, Immunology, Immunoregulation, Immunosuppression, Infections, Inflammation, Inflammation - genetics, Interleukin 1, Interleukin 6, Interleukin-1 - genetics, Interleukin-1 - physiology, Interleukins, Laboratories, Leukocytes (mononuclear), Lungs, Lymphocyte Activation - genetics, Lymphocytes, Lymphocytes T, Macrophages, Medicine, Medicine and Health Sciences, Mice, Mice, Inbred C57BL, Mice, Transgenic, Mycobacteria, Mycobacterium bovis - immunology, Mycobacterium Infections - genetics, Mycobacterium Infections - immunology, Mycobacterium Infections - prevention & control, Mycobacterium Infections - veterinary, Mycobacterium tuberculosis, Mycobacterium tuberculosis - immunology, Pathogenesis, Peripheral blood mononuclear cells, Polymorphism, Polymorphism, Single Nucleotide, Protection and preservation, Research and Analysis Methods, Rheumatoid arthritis, Single-nucleotide polymorphism, Spleen, T cells, Th1 Cells - immunology, Th17 Cells - immunology, Tuberculosis, Tuberculosis - genetics, Tuberculosis - immunology, Tuberculosis - prevention & control, Tumor necrosis factor-TNF, Tumor necrosis factor-α