Details

Autor(en) / Beteiligte

• Eulenburg, Christine
• Suling, Anna
• Neuser, Petra
• Reuss, Alexander
• Canzler, Ulrich
• Fehm, Tanja
• Luyten, Alexander
• Hellriegel, Martin
• Woelber, Linn
• Mahner, Sven
• Scherag, Andre

Titel

Propensity Scoring after Multiple Imputation in a Retrospective Study on Adjuvant Radiation Therapy in Lymph-Node Positive Vulvar Cancer

Ist Teil von

• PloS one, 2016-11, Vol.11 (11), p.e0165705-e0165705

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Propensity scoring (PS) is an established tool to account for measured confounding in non-randomized studies. These methods are sensitive to missing values, which are a common problem in observational data. The combination of multiple imputation of missing values and different propensity scoring techniques is addressed in this work. For a sample of lymph node-positive vulvar cancer patients, we re-analyze associations between the application of radiotherapy and disease-related and non-related survival. Inverse-probability-of-treatment-weighting (IPTW) and PS stratification are applied after multiple imputation by chained equation (MICE). Methodological issues are described in detail. Interpretation of the results and methodological limitations are discussed.