Details

Autor(en) / Beteiligte

• Brown, Simon H J
• Eather, Samuel R
• Freeman, Dilys J
• Meyer, Barbara J
• Mitchell, Todd W
• Ambrósio, Carlos E.

Titel

A Lipidomic Analysis of Placenta in Preeclampsia: Evidence for Lipid Storage

Ist Teil von

• PloS one, 2016-09, Vol.11 (9), p.e0163972-e0163972

Ort / Verlag

United States: Public Library of Science

Erscheinungsjahr

2016

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• In preeclampsia, maternal insulin resistance leads to defective expansion of adipocytes, enhanced adipocyte lipolysis, up-regulation of very low density lipoprotein synthesis, maternal hypertriglyceridaemia and the potential for ectopic fat storage. Our aim was to quantitate and compare the total amount and type of lipid in placenta from pregnancies complicated with preeclampsia and healthy pregnancies. Quantitative lipid analysis of lipid extracts from full thickness placental biopsies was carried out by shotgun lipidomics. Placental lipid profiles from pregnancies complicated by preeclampsia (n = 23) were compared to healthy pregnancies (n = 68), and placenta from intrauterine growth restriction pregnancies (n = 10) were used to control for gross differences in placental pathology. Placentae from pregnancies complicated with preeclampsia had higher neutral lipid content than healthy placentae (40% higher triacyglycerol (P = 0.001) and 33% higher cholesteryl ester (P = 0.004)) that was specific to preeclampsia and independent of maternal gestation.