PloS one, 2016-09, Vol.11 (9), p.e0162873
2016
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- Autor(en) / Beteiligte
- Titel
- QiShenYiQi Attenuates Renal Interstitial Fibrosis by Blocking the Activation of β-Catenin
- Ist Teil von
- PloS one, 2016-09, Vol.11 (9), p.e0162873
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Chronic kidney disease (CKD) is becoming a worldwide problem. However, current treatment options are limited. In the current study we showed that QiShenYiQi (QSYQ), a water-ethanol extract from several Chinese medicines, is a potent inhibitor of renal interstitial fibrosis. QSYQ inhibited transforming growth factor-β1 (TGF-β1)-responsive α-smooth muscle actin (α-SMA), collagen I, and fibronectin up-regulation in obstructive nephropathy and cultured cells. Administration of QSYQ also inhibited the established renal interstitial fibrosis in obstructive nephropathy. Interestingly, QSYQ selectively inhibited TGF-β1-induced β-catenin up-regulation and downstream gene transcription. Taken together, our study suggests that QSYQ selectively inhibits TGF-β1-induced β-catenin up-regulation and might have significant therapeutic potential for the treatment of renal fibrosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0162873Titel-ID: cdi_plos_journals_1820311432
- Format
- –
- Schlagworte
- Actin, Actins - antagonists & inhibitors, Animals, beta Catenin - metabolism, Biology and Life Sciences, Collagen, Collagen (type I), Diabetes, Drugs, Chinese Herbal - therapeutic use, Ethanol, Experiments, Extracellular matrix, FDA approval, Fibroblasts, Fibronectin, Fibrosis, Fibrosis - drug therapy, Gene expression, Gene regulation, Growth factors, Herbal medicine, Hospitals, Kidney diseases, Kinases, Laboratory animals, Male, Medical research, Medicine and Health Sciences, Metabolism, Muscles, Nephrology, Nephropathy, Physical Sciences, R&D, Rats, Rats, Sprague-Dawley, Renal Insufficiency, Chronic - drug therapy, Research & development, Research and Analysis Methods, Rodents, Smooth muscle, Transcription, Transcription, Genetic, Transforming growth factor, Transforming Growth Factor beta1 - physiology, Transforming growth factor-b1, β-Catenin