PloS one, 2016-07, Vol.11 (7), p.e0159899-e0159899
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1
- Ist Teil von
- PloS one, 2016-07, Vol.11 (7), p.e0159899-e0159899
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer progression. Here, we examined the role of KLF12 in colorectal cancer (CRC). Indeed, KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1). The levels of KLF12 and EGR1 correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC and could serve as a potential prognostic marker and therapeutic target.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0159899Titel-ID: cdi_plos_journals_1806086638
- Format
- –
- Schlagworte
- Adenocarcinoma, Apoptosis, Biochemistry, Biology and Life Sciences, Cancer, Cell growth, Cell Line, Tumor, Cell Survival - drug effects, Colorectal cancer, Colorectal carcinoma, Colorectal Neoplasms - genetics, Colorectal Neoplasms - mortality, Colorectal Neoplasms - pathology, Early Growth Response Protein 1 - genetics, EGR-1 protein, Esophagus, Fibroblasts, Gastric cancer, Gene expression, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Genomes, Humans, Kidneys, Kinases, Kruppel-Like Transcription Factors - metabolism, Manufacturers, Medical prognosis, Medicine and Health Sciences, Physiology, Prognosis, Promoter Regions, Genetic, Protein Binding, Proteins, Research and Analysis Methods, Rodents, Signal transduction, Transcription factors, Tumors