PloS one, 2015-08, Vol.10 (8), p.e0135576-e0135576
2015
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- Autor(en) / Beteiligte
- Titel
- High ABCG4 Expression Is Associated with Poor Prognosis in Non-Small-Cell Lung Cancer Patients Treated with Cisplatin-Based Chemotherapy
- Ist Teil von
- PloS one, 2015-08, Vol.10 (8), p.e0135576-e0135576
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- ATP-binding cassette (ABC) transporters are associated with poor response to chemotherapy, and confer a poor prognosis in various malignancies. However, the association between the expression of the ABC sub-family G member 4 (ABCG4) and prognosis in patients with non-small-cell lung cancer (NSCLC) remains unclear. NSCLC tissue samples (n = 140) and normal lung tissue samples (n = 90) were resected from patients with stage II to IV NSCLC between May 2004 and May 2009. ABCG4 mRNA and protein expressions were detected by RT-PCR, western blot, and immunohistochemistry. Patients received four cycles of cisplatin-based post-surgery chemotherapy and were followed up until May 31st, 2014. ABCG4 positivity rate was higher in NSCLC than in normal lung tissues (48.6% vs. 0%, P<0.001) and ABCG4 expression was significantly associated with poor differentiation, higher tumor node metastasis (TNM) stage, and adenocarcinoma histological type (all P<0.001). Univariate (HR = 2.284, 95%CI: 1.570-3.324, P<0.001) and multivariate (HR = 2.236, 95%CI: 1.505-3.321, P<0.001) analyses showed that ABCG4 expression was an independent factor associated with a poor prognosis in NSCLC. Patients with ABCG4-positive NSCLC had shorter median survival than ABCG4-negative NSCLC (20.1 vs. 43.2 months, P<0.001). The prognostic significance of ABCG4 expression was apparent in stages III and IV NSCLC. In conclusion, high ABCG4 expression was associated with a poor prognosis in patients with NSCLC treated with cisplatin-based chemotherapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1932-6203eISSN: 1932-6203DOI: 10.1371/journal.pone.0135576Titel-ID: cdi_plos_journals_1708528764
- Format
- –
- Schlagworte
- ABC transporters, Adenocarcinoma, Aged, Analysis, Antineoplastic Agents - administration & dosage, Antineoplastic Agents - therapeutic use, ATP Binding Cassette Transporter, Sub-Family G, ATP-Binding Cassette Transporters - genetics, ATP-Binding Cassette Transporters - metabolism, Cancer, Cancer therapies, Carcinoma, Non-Small-Cell Lung - drug therapy, Carcinoma, Non-Small-Cell Lung - genetics, Carcinoma, Non-Small-Cell Lung - pathology, Carcinoma, Non-Small-Cell Lung - surgery, Chemotherapy, Cholesterol, Cisplatin, Cisplatin - administration & dosage, Cisplatin - therapeutic use, Drug resistance, Female, Genetic Association Studies, Humans, Immunohistochemistry, Leishmania, Lung cancer, Lung diseases, Lung Neoplasms - drug therapy, Lung Neoplasms - genetics, Lung Neoplasms - pathology, Lung Neoplasms - surgery, Lungs, Male, Medical prognosis, Metastases, Middle Aged, mRNA, Non-small cell lung cancer, Non-small cell lung carcinoma, Patients, Polymerase chain reaction, Prognosis, Proteins, RNA, Surgery, Survival Analysis, Thoracic surgery, Treatment Outcome, Tumors